omega-3多烯脂肪酸对腹部肥胖患者动脉高血压发病线的影响

L. Vlasyk, V. K. Taschuk, H. Khrebtii
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摘要

高甘油三酯血症是伴有腹部肥胖的高血压患者血脂异常的一个特征性特征。这些人构成心血管并发症的风险增加,因此优化他们的治疗是极其重要的医学问题。目的是研究动态的主要脂质谱的血管和内皮功能作为动脉粥样硬化的标志,当你连接到药物ω-3多不饱和脂肪酸降压和降脂治疗的高血压和腹部肥胖患者的标准组合。原发性高血压合并腹部肥胖患者6个月标准(基础)降压药(赖诺普利,氨氯地平)和降脂治疗(阿托伐他汀)(I组)以及加入ω-3多不饱和脂肪酸(II组)。在分析6个月的治疗结果时,研究患者组中使用降压降脂联合治疗时甘油三酯降低更为明显(II组为-40,9+ 3.1%,I组为-22,7+ 2.3%,p< 0.001)。II组高密度脂蛋白胆固醇升高(II组38.6 + 2.5%,I组28.7 + 2.6%,p< 0.05),内皮血管舒张改善(II组9.86 + 0.28%,II组6.8 + 0.23%,p< 0.01)。因此,在高血压合并腹部肥胖的患者中观察到明显的血脂异常,其特征是高甘油三酯血症。加入标准的抗高血压和降脂治疗ω-3多不饱和脂肪酸有助于更有效地正常化甘油三酯。对于以内皮功能障碍为特征的高血压合并腹部肥胖患者,ω-3多不饱和脂肪酸可显著改善标准治疗。关键词:高血压,肥胖,血脂异常,内皮功能,游离-3多不饱和脂肪酸
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The influence of omega-3 polynenasic fatty acids on the pathogenetic lines of arterial hypertension in the person with abdominal obesity
Hypertriglyceridemia is a characteristic feature of dyslipidemia in hypertension in patients with concomitant abdominal obesity. These individuals constitute an increased risk of cardiovascular complications, so optimizing their treatment is extremely important medical problem. The aim is to study the dynamics of the major lipid spectrum of the blood vessels and endothelial function as a marker of atherosclerosis, when you connect to the drug ω-3 polyunsaturated fatty acids to the standard combination of antihypertensive and lipid-lowering therapy in patients with hypertension and abdominal obesity. The analysis of the dynamics of lipidohramy and vascular endothelial function in patients with essential hypertension and abdominal obesity during the 6-month standard (basic) antihypertensive (lisinopril, amlodipine) and lipid-lowering therapy (atorvastatin) (group I) and accession thereto ω-3 polyunsaturated fatty acids (group II). When analyzing the results of 6 months of treatment in the studied patient groups in triglycerides reduction was significantly more pronounced when using combination antihypertensive and lipid-lowering therapy (-40,9+3,1% in group II and -22,7+2,3% in group I, p<0,001). Also in group II was marked significantly greater increase in HDL cholesterol (38,6+2,5% in group II and 28,7+2,6% in group I, p<0,05) and improved endothelium vasodilation (9,86+0,28% in group II and 6,8+0,23%, p<0,01). Thus, in patients with hypertension and concomitant abdominal obesity observed significant dyslipidemia, a characteristic feature of which is hypertriglyceridemia. Joining the standard antihypertensive and lipid-lowering therapy ω-3 polyunsaturated fatty acids contributes significantly more effective normalization of triglycerides. For persons with hypertension and concomitant abdominal obesity is characterized by endothelial dysfunction and significant additional purpose to standard therapy ω-3 polyunsaturated fatty acids leads to a significant improvement. Key Words: arterial hypertension, obesity, dyslipidemia, endothelial function, free-3 polyunsaturated fatty acids.
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