由氧化剂和抗氧化剂失衡引起的精神健康障碍:一项文献综述研究

S. Siswanto, Arief Mukti Mindiroeseno
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引用次数: 0

摘要

健康在人类生活中是一件重要的事情,因为它是人类活动的支撑之一。通过健康的生活,每个人都可以在社会和经济上富有成效,以实现他们期望的生活目标。氧化应激是细胞产生活性氧(ROS)和抗氧化对策之间的不平衡。大脑中高氧消耗和富含脂质的环境被认为极易受到氧化应激或氧化还原失衡的影响。各种文献显示越来越多的证据表明自由基介导的病理、抗氧化能力的改变、神经毒性和神经精神疾病的炎症。氧化应激有助于复杂和衰弱性精神疾病的特定临床症状。这种复杂且异质性的氧化应激障碍对生活质量、发病率或死亡率以及认知功能产生负面影响,称为抑郁症。氧化应激在精神疾病方面受到了广泛关注,也被认为是导致抑郁症的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mental Health Disorders Due to Oxidant and Antioxidants Imbalance: A Literature Review Study
Health is a significant thing in human life because it is one of the supports for human activity. By living a healthy life, everyone can be productive socially and economically to achieve their desired life goals. Oxidative stress is an imbalance between the cellular production of Reactive Oxygen Species (ROS) and antioxidant countermeasures. The high oxygen consumption and lipid-rich environment in the brain are thought to be highly susceptible to oxidative stress or redox imbalance. Various kinds of literature show accumulating evidence of implications for free radical-mediated pathology, altered antioxidant capacity, neurotoxicity, and inflammation in neuropsychiatric disorders. Oxidative stress contributes to the specific clinical symptomatology of complex and debilitating psychiatric illnesses. This complex and heterogeneous oxidative stress disorder negatively impacts the quality of life, morbidity or mortality, and cognitive function, known as depression. Oxidative stress has received much attention concerning psychiatric illness and has also been suggested as a contributing factor to depression.
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