响应面法优化人参皂苷Re脂质体生产条件

Proceedings of the 2nd International Symposium on Artificial Intelligence for Medicine Sciences Pub Date : 2021-10-29 DOI:10.1145/3500931.3500983

Yujie Chen, Rongfa Guan, Haizhi Huang, Hao Zhong, Yujing Sun, Wei Zhang

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引用次数: 0

摘要

本研究旨在利用响应面法优化人参皂苷Re脂质体的处方。透射电镜观察了G-Re脂质体的形态。此外，用粒径分析仪测定了G-Re脂质体的微观结构和大小。膜分散法是制备脂质体的一种简便、高效的方法。结果表明，该方法的最佳制备条件为:磷脂酰胆碱/Re比为33.68，磷脂酰胆碱/胆固醇比为10.19，旋转蒸发温度为48.50℃。在最佳条件下，G-Re脂质体的粒径为173.87±4.74 nm, EE为60.91%±1.53 nm。G-Re脂质体呈球形结构，表面光滑。脂质体作为载体提高了G-Re的稳定性。

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Optimization of Conditions for Ginsenoside Re liposomes Production by Response Surface Methodology

In this study, we aimed to optimize the formulation of Ginsenoside Re liposomes using response surface methodology. A transmission electron microscope observed the morphology of G-Re liposomes. Additionally, the microstructure and size of G-Re liposomes were determined by a particle size analyzer. The film dispersion method is a simple and efficient method for liposome preparation. The results showed that the optimal preparation conditions for this method were: phosphatidylcholine/Re ratio of 33.68, phosphatidylcholine/cholesterol ratio of 10.19, and rotary evaporation temperature of 48.50 °C. Under the optimal conditions, the particle size and EE of G-Re liposomes were 173.87 ± 4.74 nm and 60.91% ±1.53, respectively. The G-Re liposomes showed a spherical structure with a smooth surface. The liposomes as carriers improved the stability of G-Re.

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Proceedings of the 2nd International Symposium on Artificial Intelligence for Medicine Sciences

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