利用局部结构预测挖掘蛋白质中的残馀接触

Proceedings IEEE International Symposium on Bio-Informatics and Biomedical Engineering Pub Date : 2000-11-08 DOI:10.1109/BIBE.2000.889604

Mohammed J. Zaki, Shanrong Jin, C. Bystroff

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引用次数: 57

摘要

在本文中，我们基于蛋白质折叠的分层成核-传播模型开发了数据挖掘技术来预测蛋白质残基(或氨基酸)之间的三维接触电位。我们采用了一种混合方法，使用隐马尔可夫模型(HMM)提取折叠起始位点，然后使用关联挖掘来发现接触电位。新的混合方法比以前报道的方法获得了更好的精度结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mining residue contacts in proteins using local structure predictions

In this paper, we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleation-propagation model of protein folding. We apply a hybrid approach, using a hidden Markov model (HMM) to extract folding initiation sites, and then apply association mining to discover contact potentials. The new hybrid approach achieves accuracy results better than those reported previously.

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Proceedings IEEE International Symposium on Bio-Informatics and Biomedical Engineering

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