使用可调高通角的神经调节剂的伪影恢复

Stefan Reich, D. Fritschi, Mark A. Sporer, M. Ortmanns
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引用次数: 2

摘要

在神经调节系统中,刺激引起的伪影比记录的神经信号大几个数量级。最近的一些出版物提出了具有高动态范围的记录仪前端,以应对刺激伪影,从而避免了关闭开关和由此导致的记录仪盲时间。然而,由于信号摆幅要求,这通常是以有限的一级放大为代价的,从而降低了噪声效率因子(NEF)。在本文中,我们建议将消隐开关与基于伪电阻的前端高通角频率的调谐机制相结合。这允许在人工制品恢复期间暂时提高沉降速度,这样在刺激事件发生后的几十毫秒内就可以开始不受干扰的记录。伪影恢复方案使用集成的最先进的神经调节剂进行演示,并提出体外测量以验证其可用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Artifact-Recovery in Neuromodulators using Tunable High-Pass Corners
In neuromodulation systems, stimulation causes artifacts which are orders of magnitude larger than the recorded neural signal. Several recent publications have proposed recorder front-ends with high dynamic range to cope with stimulation artifacts, thereby avoiding blanking switches and the resulting recorder blind-time. However, this usually comes at the cost of limited first-stage amplification due to signal swing requirements, thus degrading the noise efficiency factor (NEF). In this paper, we propose to instead combine blanking switches with a tuning mechanism on the pseudo-resistor based high-pass corner frequency of the frontend. This allows to temporarily increase the settling speed during artifact-recovery, such that undisturbed recording can commence few tens of milli-seconds after e.g., a stimulation event. The artifact-recovery scheme is demonstrated using an integrated state-of-the-art neuromodulator, and in-vitro measurements are presented to validate its usability.
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