The significance of component-resolved allergy diagnostics in atopic dermatitis patients when prescribing allergen-specific immunotherapy

The paper presents two clinical cases of patients with severe atopic dermatitis (AD) with polyvalent sensitization: in an adult patient and in a child. Standard topical and systemic therapy proved to be an insufficiently effective strategy in these patients. Both patients underwent component-resolved allergy diagnostics, which made it possible to identify the causally significant components of allergens, sensitization to which affects the course of AD. On the basis of the survey, indications for ASIT with causally significant allergens were determined. The performed treatment made it possible to achieve non-drug remission not only of AD, but also of concomitant respiratory allergic diseases. The cases presented by us demonstrate the efficacy and safety of ASIT in patients with proven sensitization to causally significant allergens based on component allergy diagnostics.