Amanj Saber, Rashida Hussain, S. Nakka, S. Hugosson
{"title":"金黄色葡萄球菌对慢性鼻窦炎鼻上皮细胞NLRP3炎性体、caspase-1和IL-1β表达的影响","authors":"Amanj Saber, Rashida Hussain, S. Nakka, S. Hugosson","doi":"10.17352/2455-1759.000087","DOIUrl":null,"url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is an inflammatory disease. Excessive NLRP3 inflammasome activation and it’s downstream responses, plays a role in the pathogenesis of CRS. \nThe context and purpose of the study: The aim of the study was to elucidate the effect of Staphylococcus aureus and budesonide on the mRNA expression and the biologic role (caspase-1 activation and IL-1β secretion) of NLRP3 inflammasome in primary nasal epithelial cells (NECs) in CRS patients and healthy controls.","PeriodicalId":440305,"journal":{"name":"Archives of Otolaryngology and Rhinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Effect of Staphylococcus aureus on the NLRP3 inflammasome, caspase-1 and IL-1β expression in the nasal epithelial cells in chronic rhinosinusitis\",\"authors\":\"Amanj Saber, Rashida Hussain, S. Nakka, S. Hugosson\",\"doi\":\"10.17352/2455-1759.000087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Chronic rhinosinusitis (CRS) is an inflammatory disease. Excessive NLRP3 inflammasome activation and it’s downstream responses, plays a role in the pathogenesis of CRS. \\nThe context and purpose of the study: The aim of the study was to elucidate the effect of Staphylococcus aureus and budesonide on the mRNA expression and the biologic role (caspase-1 activation and IL-1β secretion) of NLRP3 inflammasome in primary nasal epithelial cells (NECs) in CRS patients and healthy controls.\",\"PeriodicalId\":440305,\"journal\":{\"name\":\"Archives of Otolaryngology and Rhinology\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Otolaryngology and Rhinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17352/2455-1759.000087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Otolaryngology and Rhinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/2455-1759.000087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Staphylococcus aureus on the NLRP3 inflammasome, caspase-1 and IL-1β expression in the nasal epithelial cells in chronic rhinosinusitis
Background: Chronic rhinosinusitis (CRS) is an inflammatory disease. Excessive NLRP3 inflammasome activation and it’s downstream responses, plays a role in the pathogenesis of CRS.
The context and purpose of the study: The aim of the study was to elucidate the effect of Staphylococcus aureus and budesonide on the mRNA expression and the biologic role (caspase-1 activation and IL-1β secretion) of NLRP3 inflammasome in primary nasal epithelial cells (NECs) in CRS patients and healthy controls.
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