Chaitali Biswas, A. Roy, D. P. Bhattacharjee, Suhrita Paul
{"title":"关节镜下膝关节手术术后镇痛:关节内可乐定与右美托咪定的比较","authors":"Chaitali Biswas, A. Roy, D. P. Bhattacharjee, Suhrita Paul","doi":"10.32677/EJMS.2019.V04.I02.002","DOIUrl":null,"url":null,"abstract":"Background: Arthroscopic surgery is associated with variable amount of postoperative pain and sometimes the pain is considerable. To provide postoperative analgesia after arthroscopic knee surgery, various medications have been administered intra-articularly. Aim: To compare the postoperative analgesic effects of intra-articular clonidine and dexmedetomidine administered as adjuvants with local anesthetic levobupivacaine in patients undergoing arthroscopic knee surgery. Methods: Sixty patients undergoing elective knee arthroscopy were randomly assigned to one of the following groups containing 20 patients each. Group L patients received 19 ml of 0.25% levobupivacaine and 1 ml of isotonic saline (20 ml in total) intra-articularly. Group C patients received 150µg [1ml] of clonidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Group D patients received 100 µg (1 ml) of dexmedetomidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Analgesic effect was evaluated by measuring pain intensity (VAS score) and duration of analgesia. Results: A longer delay was observed between intra-articular injection of study medication and first requirement of supplementary analgesic in group C (10.44 ± 4.6 hours) and in group D (10.72 ± 5.6 hours) compared to group L (6.18 ± 1.8 hours). Total consumption of diclofenac sodium in first 24 hours in postoperative period was significantly less in group C and D. No significant side effects were noted. Conclusion: Both clonidine and dexmedetomidine, added as adjuncts to levobupivacaine in patients undergoing arthroscopic knee surgery, improve the quality and duration of post operative analgesia.","PeriodicalId":386906,"journal":{"name":"Volume 4 Issue 2 Apr - Jun 2019","volume":"42 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"POST-OPERATIVE ANALGESIA IN ARTHROSCOPIC KNEE SURGERY: A COMPARISON BETWEEN INTRA-ARTICULAR CLONIDINE AND DEXMEDETOMIDINE\",\"authors\":\"Chaitali Biswas, A. Roy, D. P. Bhattacharjee, Suhrita Paul\",\"doi\":\"10.32677/EJMS.2019.V04.I02.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Arthroscopic surgery is associated with variable amount of postoperative pain and sometimes the pain is considerable. To provide postoperative analgesia after arthroscopic knee surgery, various medications have been administered intra-articularly. Aim: To compare the postoperative analgesic effects of intra-articular clonidine and dexmedetomidine administered as adjuvants with local anesthetic levobupivacaine in patients undergoing arthroscopic knee surgery. Methods: Sixty patients undergoing elective knee arthroscopy were randomly assigned to one of the following groups containing 20 patients each. Group L patients received 19 ml of 0.25% levobupivacaine and 1 ml of isotonic saline (20 ml in total) intra-articularly. Group C patients received 150µg [1ml] of clonidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Group D patients received 100 µg (1 ml) of dexmedetomidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Analgesic effect was evaluated by measuring pain intensity (VAS score) and duration of analgesia. Results: A longer delay was observed between intra-articular injection of study medication and first requirement of supplementary analgesic in group C (10.44 ± 4.6 hours) and in group D (10.72 ± 5.6 hours) compared to group L (6.18 ± 1.8 hours). Total consumption of diclofenac sodium in first 24 hours in postoperative period was significantly less in group C and D. No significant side effects were noted. Conclusion: Both clonidine and dexmedetomidine, added as adjuncts to levobupivacaine in patients undergoing arthroscopic knee surgery, improve the quality and duration of post operative analgesia.\",\"PeriodicalId\":386906,\"journal\":{\"name\":\"Volume 4 Issue 2 Apr - Jun 2019\",\"volume\":\"42 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Volume 4 Issue 2 Apr - Jun 2019\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32677/EJMS.2019.V04.I02.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Volume 4 Issue 2 Apr - Jun 2019","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32677/EJMS.2019.V04.I02.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
POST-OPERATIVE ANALGESIA IN ARTHROSCOPIC KNEE SURGERY: A COMPARISON BETWEEN INTRA-ARTICULAR CLONIDINE AND DEXMEDETOMIDINE
Background: Arthroscopic surgery is associated with variable amount of postoperative pain and sometimes the pain is considerable. To provide postoperative analgesia after arthroscopic knee surgery, various medications have been administered intra-articularly. Aim: To compare the postoperative analgesic effects of intra-articular clonidine and dexmedetomidine administered as adjuvants with local anesthetic levobupivacaine in patients undergoing arthroscopic knee surgery. Methods: Sixty patients undergoing elective knee arthroscopy were randomly assigned to one of the following groups containing 20 patients each. Group L patients received 19 ml of 0.25% levobupivacaine and 1 ml of isotonic saline (20 ml in total) intra-articularly. Group C patients received 150µg [1ml] of clonidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Group D patients received 100 µg (1 ml) of dexmedetomidine added to 19 ml of 0.25% levobupivacaine intra-articularly (total volume 20 ml). Analgesic effect was evaluated by measuring pain intensity (VAS score) and duration of analgesia. Results: A longer delay was observed between intra-articular injection of study medication and first requirement of supplementary analgesic in group C (10.44 ± 4.6 hours) and in group D (10.72 ± 5.6 hours) compared to group L (6.18 ± 1.8 hours). Total consumption of diclofenac sodium in first 24 hours in postoperative period was significantly less in group C and D. No significant side effects were noted. Conclusion: Both clonidine and dexmedetomidine, added as adjuncts to levobupivacaine in patients undergoing arthroscopic knee surgery, improve the quality and duration of post operative analgesia.