{"title":"水杨酸延长小鼠次腭的体外封闭。","authors":"I Saxén","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In organ culture sodium salicylate and acetylsalicylic acid in a 1.4 mM concentration caused prolongation of the time needed for the closure of the mouse secondary palate. The response of Strain A and the hybrids CBA X A was more distinct than that of Strain CBA. The mitotic rate, calculated from serial sections, was significantly reduced in the salicylate-treated shelves in both strains. The extrapolation of the results to an in vivo situation is discussed in the light of different theories of the mechanism of cleft palate formation.</p>","PeriodicalId":21511,"journal":{"name":"Scandinavian journal of dental research","volume":"83 1","pages":"202-8"},"PeriodicalIF":0.0000,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prolonged in vitro closure of the mouse secondary palate by salicylates.\",\"authors\":\"I Saxén\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In organ culture sodium salicylate and acetylsalicylic acid in a 1.4 mM concentration caused prolongation of the time needed for the closure of the mouse secondary palate. The response of Strain A and the hybrids CBA X A was more distinct than that of Strain CBA. The mitotic rate, calculated from serial sections, was significantly reduced in the salicylate-treated shelves in both strains. The extrapolation of the results to an in vivo situation is discussed in the light of different theories of the mechanism of cleft palate formation.</p>\",\"PeriodicalId\":21511,\"journal\":{\"name\":\"Scandinavian journal of dental research\",\"volume\":\"83 1\",\"pages\":\"202-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of dental research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of dental research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在器官培养中，1.4 mM浓度的水杨酸钠和乙酰水杨酸导致小鼠次级上颚闭合所需时间延长。菌株A和杂交菌株CBA X A的反应比菌株CBA更明显。从连续切片计算，有丝分裂率在水杨酸处理的架子中显著降低。根据不同的腭裂形成机制理论，讨论了这些结果在体内情况下的外推。
Prolonged in vitro closure of the mouse secondary palate by salicylates.
In organ culture sodium salicylate and acetylsalicylic acid in a 1.4 mM concentration caused prolongation of the time needed for the closure of the mouse secondary palate. The response of Strain A and the hybrids CBA X A was more distinct than that of Strain CBA. The mitotic rate, calculated from serial sections, was significantly reduced in the salicylate-treated shelves in both strains. The extrapolation of the results to an in vivo situation is discussed in the light of different theories of the mechanism of cleft palate formation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
