肿瘤巨细胞在口腔鳞状细胞癌中的意义1例报告

S. Khan
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引用次数: 0

摘要

背景:口腔鳞状细胞癌(OSCC)是口腔最常见的癌症。OSCC表现出一些典型的组织病理学特征,如发育不良的上皮细胞伴不同程度的鳞状分化。这些组织病理学特征使得常规鳞状细胞癌的诊断相对容易。然而,一些病例显示出某些独特的特征,有助于确定疾病的预后。这些特征包括上皮-间质相互作用、间质透明化、透明细胞改变、间质结缔组织增生、神经周围浸润、血管浸润、组织嗜酸性粒细胞增多、巨细胞和三级淋巴滤泡形成。鳞癌中巨细胞的存在可能是异物对角蛋白反应的结果,也可能是低分化癌中恶性肿瘤巨细胞的形成。巨细胞表现出多形性特征有助于预测疾病的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance Of Tumor Giant Cells In Oral Squamous Cell Carcinoma: A Case Report
Background : Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity. OSCC presents with some typical histopathological characteristics like dysplastic epithelial cells with variable degrees of squamous differentiation. These histopathological features make it relatively easy to diagnose conventional squamous cell carcinoma. However, some cases show certain unique features that help in determining the prognosis of the disease. These features include epithelial-mesenchymal interaction, stromal hyalinization, clear cell change, stromal desmoplasia, perineural invasion, vascular invasion, tissue eosinophilia, giant cells and tertiary lymphoid follicle formation. The presence of giant cells in OSCC can be the result of foreign body reaction to keratin or due to formation of malignant tumor giant cells in poorly differentiated carcinomas. The giant cells showing pleomorphic features can be helpful in predicting the prognosis of the disease.
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