ChAdOx1 nCoV-19疫苗在COVID-19患者中的有效性:一项回顾性队列研究

Shuva Das, R. Ripon, Md. Safaet Hossain Sujan, N. I. Tumpa, A. Khan, Akhi Dhar, R. Biswas, Md Minhazul Hoque, Sujan Rudra, Mohosina Akter, M Zahid Hasan, K. Koly
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引用次数: 0

摘要

目前尚不清楚COVID-19疫苗在预防普通人群中新型严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染方面的效果如何。该研究表明,安全有效的COVID-19疫苗接种如果得到广泛传播,可能有助于控制这场大流行。本研究旨在调查ChAdOx1 nCoV-19疫苗在接种和未接种人群中的有效性。一项回顾性多中心队列研究包括来自三家不同医院的1244名COVID-19阳性患者,这些患者在2021年4月至6月期间是否接种了适当的疫苗。资料收集方法为面对面调查,临床调查方法为观察。采用描述性统计和Cox比例风险模型进行生存分析。在参与者中,69%接种疫苗的队列不需要住院治疗,97%成功地从感染中恢复。在年龄方面,与未接种疫苗的人群相比,疫苗的有效性从81%到92%不等。ChAdOx1 nCoV-19疫苗在60-69岁人群中更有效,死亡风险比未接种组降低92% [HR比- 0.081(0.036 - 0.179),P=0.0001]。该研究发现,ChAdOx1 nCoV-19疫苗对受体非常有效。COVID-19疫苗接种与疾病严重程度、住院率、疾病早期康复和死亡率降低的可能性显著相关。亚洲医学杂志。Res. 2022, 8 (4), 251-263
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of the ChAdOx1 nCoV-19 vaccination among COVID-19 patients: a retrospective cohort study
It is currently unknown how effective the COVID-19 vaccine is at preventing new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among the general population. The study suggests that a safe and efficient vaccination against the COVID-19 could help manage this pandemic if widely distributed. The present study aimed to investigate the effectiveness of the ChAdOx1 nCoV-19 vaccine in between vaccinated and unvaccinated cohorts. A retrospective multicenter cohort study comprised 1244 COVID-19 positive patients enrolled in this study from three different hospitals among patients who had been appropriately vaccinated or not between April and June 2021. Data were collected by face-to-face survey, and clinical investigations were obtained by observation. Descriptive statistics and the Cox proportional hazard model of survival analysis were performed in the study. Among the participants, 69% of vaccinated cohorts did not require hospitalization, and 97% successfully recovered from the infection. In respect of age, compared with unvaccinated cohorts, the vaccine effectiveness varied from 81% to 92%. The ChAdOx1 nCoV-19 vaccine was more effective among those aged 60-69 years old and reduced 92% hazard of death than the unvaccinated group [HR ratio - 0.081(.036-.179), P=0.0001]. The study found the ChAdOx1 nCoV-19 vaccine is highly effective for receivers. The COVID-19 vaccination demonstrated a significant correlation with a reduced probability of disease severity, hospital admission rate, early recovery from illness, and mortality. Asian J. Med. Biol. Res. 2022, 8 (4), 251-263
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