基于复杂形态计量学分析的健康男性海绵动脉形态结构的年龄动态

A. N. Strelkov, A. Astrakhantsev, S. Snegur
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Detailed morphometric analysis was carried out according to the original method by measuring the perimeter and then calculating the area of the corresponding component of the vascular wall.Results. In the studied age range from 17 to 74 years, there was an increase in the total area of the CA from 0.76 mm2 in the age period of 17–21 years to 0.99 mm2 in the period of 36–60 years and a decrease to 0.43 mm2 at the age of 61–74 years. А similar increase in absolute indicators of the area of the lumen with a decrease in old age was revealed. The absolute area of intimacy and media, increasing by the age of 36–60 years, also significantly decreases in the age range of 61–74 years. At the same time, the relative area of intima to the vessel lumen has insignificant fluctuations, remaining a stable value in all age groups. The specific area of intima relative to the entire area of the vessel as a whole has a stable indicator, increasing in old age. The Kernogan Index tends to decrease throughout the studied age range from 33 to 26 %, which indicates the preservation of the spacecraft throughput in all the studied groups, including the elderly. This is also evidenced by the dynamics of the ratio of the diameter of the CA lumen to the thickness of the vessel wall, including intima and media, reaching maximum values of 4.15 by the period of 36–60 years, remaining at a high level of 3.53 and in the oldest age group. At the same time, the specific share of media significantly decreases in all groups of the studied age range of 17–74 years from 62.1 to 50.5 %. The ratio of the maximum lumen area of the vessel to the minimum as an indicator of the potential possibility of increasing the lumen of the spacecraft turned out to be maximum atthe ages of 17–21 years and 22–35 years,significantly decreasing in older age groupsfrom 176 to 130 %.Conclusion. 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引用次数: 0

摘要

背景。勃起功能障碍与全体性血管疾病有关,在更大程度上与年龄有关,而在正常情况下不同年龄男性海绵动脉(CA)形态状态的文献资料不足。在没有动脉粥样硬化和高血压征象的情况下,对不同年龄的男性CA进行详细的形态计量学评估。材料和方法。材料是在尸检中获得的具有配对CA的海绵状体的横向碎片(58个观察,共检查了116个CA)。采用苏木精与伊红、品红精与微富新、Mallory染色。根据原方法进行了详细的形态计量学分析,测量了血管壁的周长,然后计算了相应成分的面积。在17 ~ 74岁的研究年龄范围内,CA总面积从17 ~ 21岁的0.76 mm2增加到36 ~ 60岁的0.99 mm2,在61 ~ 74岁时减少到0.43 mm2。А管腔面积的绝对指标也有类似的增加,随着年龄的增长而减少。亲密关系和媒体的绝对面积在36-60岁年龄段增加,在61-74岁年龄段也显著减少。同时,血管内膜相对于血管腔的面积波动不明显,各年龄组均保持稳定。相对于整个血管面积而言,内膜的具体面积有一个稳定的指标,随着年龄的增长而增加。在研究的年龄范围内,Kernogan指数趋于下降,从33%到26%,这表明在所有研究群体中,包括老年人,航天器的吞吐量都保持不变。CA管腔直径与血管壁(包括内膜和中膜)厚度之比的动态变化也证明了这一点,在36-60岁期间达到最大值4.15,在年龄最大的年龄组中保持在3.53的高水平。与此同时,在17-74岁年龄段的所有群体中,媒体的具体份额都显著下降,从62.1%降至50.5%。航天器最大管腔面积与最小管腔面积之比在17-21岁和22-35岁年龄段最大,在老年群体中从176%显著下降到130%。航天器的年龄相关重构是航天器在17-21岁至36-60岁期间相当稳定的形态测量参数,随着年龄的增长,管腔和整个航天器的绝对面积下降。在血管壁结构中,中膜的比例显著下降,内膜的比例增加。同时,直到36-60岁,航天器的吞吐量指标都保持在较高水平。进一步研究血管病理学中的CA可能有助于理解勃起功能障碍与男性年龄相关的原因和机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age dynamics of the morphological structure of the cavernous arteries in healthy men according to complex morphometric analysis
Background. Erectile dysfunction is associated with systemic vascular diseases and, to a greater extent, with age, while there is insufficient data in the literature on the morphological state of the cavernous arteries (CA) in men of different ages in normal.Aim. A detailed morphometric assessment of the CA of men of various ages in the absence of signs of atherosclerosis and hypertension.Materials and methods. The material was transverse fragments of cavernous bodies with paired CA obtained during autopsy (58 observations, a total of 116 CA were examined). Hematoxylin and eosin, fuchsylin and picrofuxin, and Mallory staining were used. Detailed morphometric analysis was carried out according to the original method by measuring the perimeter and then calculating the area of the corresponding component of the vascular wall.Results. In the studied age range from 17 to 74 years, there was an increase in the total area of the CA from 0.76 mm2 in the age period of 17–21 years to 0.99 mm2 in the period of 36–60 years and a decrease to 0.43 mm2 at the age of 61–74 years. А similar increase in absolute indicators of the area of the lumen with a decrease in old age was revealed. The absolute area of intimacy and media, increasing by the age of 36–60 years, also significantly decreases in the age range of 61–74 years. At the same time, the relative area of intima to the vessel lumen has insignificant fluctuations, remaining a stable value in all age groups. The specific area of intima relative to the entire area of the vessel as a whole has a stable indicator, increasing in old age. The Kernogan Index tends to decrease throughout the studied age range from 33 to 26 %, which indicates the preservation of the spacecraft throughput in all the studied groups, including the elderly. This is also evidenced by the dynamics of the ratio of the diameter of the CA lumen to the thickness of the vessel wall, including intima and media, reaching maximum values of 4.15 by the period of 36–60 years, remaining at a high level of 3.53 and in the oldest age group. At the same time, the specific share of media significantly decreases in all groups of the studied age range of 17–74 years from 62.1 to 50.5 %. The ratio of the maximum lumen area of the vessel to the minimum as an indicator of the potential possibility of increasing the lumen of the spacecraft turned out to be maximum atthe ages of 17–21 years and 22–35 years,significantly decreasing in older age groupsfrom 176 to 130 %.Conclusion. Age-related remodeling of the spacecraft consistsin fairly stable morphometric parameters of the spacecraft in the age range from 17–21 years to a period of 36–60 years with a decrease at an older age, when a decrease in the absolute area of the lumen and the entire spacecraft isrevealed. A significant progressive decrease in the specific proportion of media and an increase in the proportion of intima in the structure of the vessel wall are shown. At the same time, up to the age of 36–60 years, spacecraft maintain their throughput indicators at a high level. Further studies of CA in vascular pathology may be useful in understanding the causes and mechanisms of the association of erectile dysfunction with the age of men. 
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