A Model for Simulation of Human Sinoatrial Node Action Potential

Upon discovery of new biological mechanisms inside cardiomyocytes modern models of sinoatrial node action potential have been steadily increasing in complexity. Researchers who design complex models try to implement as many independent currents as possible to keep their models up to date. This paper presents an improved parallel conductance model with parameters suitable for simulation of human sinoatrial node action potential. In this model the independent membrane currents were replaced by four main current groups (K-related, Na-related, Ca-related and transporter-related) to form four total currents. The resulting total currents were compared with corresponding total currents formed from the sum of independent currents from a different, more complex model. This approach can be used to simulate sinoatrial node action potentials similar to those in more complex models while keeping a reduced number of parameters and differential equations.