Alexander Squires, J. Oshinski, J. Lamanna, Z. Tse
{"title":"SpinoTemplate: mri引导下的脊髓注射平台","authors":"Alexander Squires, J. Oshinski, J. Lamanna, Z. Tse","doi":"10.1142/S2424905X16400067","DOIUrl":null,"url":null,"abstract":"Patients with amyotrophic lateral sclerosis have limited treatment options and a 20% survival rate within five years of diagnosis. Small animal models show promise for halting the associated neurodegeneration when cellular therapeutics are delivered to the ventral horn of the spinal cord. A template-based guidance system was developed to facilitate percutaneous injections under MRI guidance to improve upon existing invasive and time-consuming surgical techniques. Procedure duration was 30min plus 5min per insertion, with a mean error of <2mm.","PeriodicalId":447761,"journal":{"name":"J. Medical Robotics Res.","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"SpinoTemplate: A Platform for MRI-Guided Spinal Cord Injections\",\"authors\":\"Alexander Squires, J. Oshinski, J. Lamanna, Z. Tse\",\"doi\":\"10.1142/S2424905X16400067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Patients with amyotrophic lateral sclerosis have limited treatment options and a 20% survival rate within five years of diagnosis. Small animal models show promise for halting the associated neurodegeneration when cellular therapeutics are delivered to the ventral horn of the spinal cord. A template-based guidance system was developed to facilitate percutaneous injections under MRI guidance to improve upon existing invasive and time-consuming surgical techniques. Procedure duration was 30min plus 5min per insertion, with a mean error of <2mm.\",\"PeriodicalId\":447761,\"journal\":{\"name\":\"J. Medical Robotics Res.\",\"volume\":\"16 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"J. Medical Robotics Res.\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1142/S2424905X16400067\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"J. Medical Robotics Res.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S2424905X16400067","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SpinoTemplate: A Platform for MRI-Guided Spinal Cord Injections
Patients with amyotrophic lateral sclerosis have limited treatment options and a 20% survival rate within five years of diagnosis. Small animal models show promise for halting the associated neurodegeneration when cellular therapeutics are delivered to the ventral horn of the spinal cord. A template-based guidance system was developed to facilitate percutaneous injections under MRI guidance to improve upon existing invasive and time-consuming surgical techniques. Procedure duration was 30min plus 5min per insertion, with a mean error of <2mm.