{"title":"来自Erythrina fusca L的p霍尔化合物的抗癌活性。","authors":"Novi Anggreini","doi":"10.35799/PMJ.1.1.2018.19645","DOIUrl":null,"url":null,"abstract":"AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L. Novi Anggreini1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Natural Products Chemistry Research Group, Organic Chemistry Division,Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesiamulyadi-t@fst.unair.ac.id ABSTRACT Two pterocarpans namely as sandwicensin (1) dan phaseollin (2) were isolated from the stem bark of. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS, 1D and 2D NMR. Compounds 1–2 were evaluated for their anticancer against murin leukemia P-388 cells showing their IC50 were 1.20 and 1.05 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., sandwicensin, phaseollin, anticancer ABSTRAK Dua senyawa pterokarpan yakni sandwisensin (1) dan paseollin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa pterokarpan ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murin leukemia P-388 memperlihatkan IC50 1,20 dan 1,05 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., sandwisensin, paesolin, antikanker ","PeriodicalId":341679,"journal":{"name":"Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L.\",\"authors\":\"Novi Anggreini\",\"doi\":\"10.35799/PMJ.1.1.2018.19645\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L. Novi Anggreini1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Natural Products Chemistry Research Group, Organic Chemistry Division,Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesiamulyadi-t@fst.unair.ac.id ABSTRACT Two pterocarpans namely as sandwicensin (1) dan phaseollin (2) were isolated from the stem bark of. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS, 1D and 2D NMR. Compounds 1–2 were evaluated for their anticancer against murin leukemia P-388 cells showing their IC50 were 1.20 and 1.05 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., sandwicensin, phaseollin, anticancer ABSTRAK Dua senyawa pterokarpan yakni sandwisensin (1) dan paseollin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa pterokarpan ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murin leukemia P-388 memperlihatkan IC50 1,20 dan 1,05 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., sandwisensin, paesolin, antikanker \",\"PeriodicalId\":341679,\"journal\":{\"name\":\"Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)\",\"volume\":\"33 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35799/PMJ.1.1.2018.19645\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35799/PMJ.1.1.2018.19645","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L. Novi Anggreini1)， Ratih Dewi Saputri1)， Tjitjik Srie Tjahjandarie1)， Mulyadi tanjun1 *)1) Airlangga大学科学技术学院化学系有机化学研究室，Surabaya 60115, Indonesiamulyadi-t@fst.unair.ac.id摘要从一种植物的茎皮中分离得到了两种pterocarpan，分别为三明治素(1)和phaseollin(2)。利用紫外、红外、质谱、一维和二维核磁共振等光谱数据对其结构进行了分析。化合物1 ~ 2对小鼠白血病P-388细胞的抑癌活性分别为1.20µg/ml和1.05µg/ml，具有很高的活性。【关键词】红鲌，夹心素，相参素，抗癌【关键词】红鲌，夹心素(1)，相参素(2)，相参素(1)，相参素(1)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素(2)，相参素，相参素，相参素，相参素，相参素，相参素，相参素，相参素)Uji aktivitas anti - kanker senyawa 1 - 2 terhadap sel murin leukemia P-388 memperlihatkan IC50 1,20 dan 1,05µg/ml yang diategorikan sangat aktif。Kata kunci:赤藓，沙参素，paesolin，抗结核
AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L.
AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L. Novi Anggreini1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Natural Products Chemistry Research Group, Organic Chemistry Division,Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesiamulyadi-t@fst.unair.ac.id ABSTRACT Two pterocarpans namely as sandwicensin (1) dan phaseollin (2) were isolated from the stem bark of. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS, 1D and 2D NMR. Compounds 1–2 were evaluated for their anticancer against murin leukemia P-388 cells showing their IC50 were 1.20 and 1.05 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., sandwicensin, phaseollin, anticancer ABSTRAK Dua senyawa pterokarpan yakni sandwisensin (1) dan paseollin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa pterokarpan ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murin leukemia P-388 memperlihatkan IC50 1,20 dan 1,05 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., sandwisensin, paesolin, antikanker
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
