Yulia Ulianova, Yu. V. Ermolenko, V. Trukhan, Vladimir U. Ivanov, Ildar R. Iusupov, Alexander Alexander, S. Gelperina
{"title":"基于PLGA微球的利匹韦林长效注射制剂的研制","authors":"Yulia Ulianova, Yu. V. Ermolenko, V. Trukhan, Vladimir U. Ivanov, Ildar R. Iusupov, Alexander Alexander, S. Gelperina","doi":"10.11159/nddte22.143","DOIUrl":null,"url":null,"abstract":"The rilpivirine-loaded spherical and monodisperse PLGA microspheres were produced by microfluidic technology. The technological parameters such as the flow rate ratio and the rilpivirine/PLGA ratio were optimized to ensure desired microspheres size and higher encapsulation efficiency of rilpivirine. The microspheres exhibited a continuous drug release characterized by only a minor burst effect. These results suggest that the PLGA microspheres loaded with rilpivirine is a promising approach to the injectable depot formulation of this drug.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of a Long-Acting Injectable Formulation of Rilpivirine Based On PLGA Microspheres\",\"authors\":\"Yulia Ulianova, Yu. V. Ermolenko, V. Trukhan, Vladimir U. Ivanov, Ildar R. Iusupov, Alexander Alexander, S. Gelperina\",\"doi\":\"10.11159/nddte22.143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The rilpivirine-loaded spherical and monodisperse PLGA microspheres were produced by microfluidic technology. The technological parameters such as the flow rate ratio and the rilpivirine/PLGA ratio were optimized to ensure desired microspheres size and higher encapsulation efficiency of rilpivirine. The microspheres exhibited a continuous drug release characterized by only a minor burst effect. These results suggest that the PLGA microspheres loaded with rilpivirine is a promising approach to the injectable depot formulation of this drug.\",\"PeriodicalId\":276715,\"journal\":{\"name\":\"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology\",\"volume\":\"33 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11159/nddte22.143\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11159/nddte22.143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Development of a Long-Acting Injectable Formulation of Rilpivirine Based On PLGA Microspheres
The rilpivirine-loaded spherical and monodisperse PLGA microspheres were produced by microfluidic technology. The technological parameters such as the flow rate ratio and the rilpivirine/PLGA ratio were optimized to ensure desired microspheres size and higher encapsulation efficiency of rilpivirine. The microspheres exhibited a continuous drug release characterized by only a minor burst effect. These results suggest that the PLGA microspheres loaded with rilpivirine is a promising approach to the injectable depot formulation of this drug.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
