胡芦巴对链脲佐菌素诱导的糖尿病大鼠胸腺结缔组织数量的影响

Bangladesh Journal of Anatomy Pub Date : 2011-08-02 DOI:10.3329/BJA.V9I1.8149

D. Mondal, MM Ahmed, P. Chowdhury, A. Khanom, S. Mohal, S. Ara, K. Shamim

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引用次数: 0

摘要

背景:糖尿病引起胸腺结缔组织数量的显著增加。葫芦巴有降血糖的作用。研究胡芦巴籽/胡芦巴籽对糖尿病胸腺切片结缔组织数量增加是否有预防作用。研究类型:对Long Evans大鼠进行实验研究，根据其饮食喂养和药物治疗的不同，将其分为三组。单位:前身为孟加拉谢赫·穆吉布医科大学(BSMMU)和孟加拉国糖尿病、内分泌和代谢疾病研究与康复研究所(BIRDEM)的研究生医学研究所(IPGMR)解剖学系。实验对象:年龄50 ~ 60日龄，体重72 ~ 174gm的健康雄性Long Evans大鼠58只。主要观察指标:各组大鼠胸腺组织结缔组织数量的变化。结果:非糖尿病对照组胸腺切片结缔组织的增加量低于糖尿病对照组。另一方面，葫芦巴治疗的糖尿病大鼠胸腺切片结缔组织数量的增加也低于糖尿病对照组胸腺切片结缔组织数量，但与非糖尿病对照组胸腺切片结缔组织数量大致相似。结论:胡芦巴对链脲佐菌素所致糖尿病胸腺区结缔组织数量增加有抑制作用。然而，建议进一步研究胡芦巴作为一种安全、有用、有效的药物，以减少胸腺区结缔组织数量的增加，通过作为抗糖尿病药物改善糖尿病病情。关键词:糖尿病;结缔组织;胡芦巴;胸腺DOI: http://dx.doi.org/ 10.3329/bja.v9i1.8149孟加拉解剖学杂志2011年1月，Vol. 9 No. 1 pp 49-52

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Effect of Fenugreek (Methi) on Amount of Connective Tissue in Thymic Sections in Streptozotocin-induced Diabetic Rats

Context: Diabetes mellitus causes a marked increased in amount of connective tissue in thymus. Fenugreek has the hypoglycaemic effect. The study was carried out to find out whether Trigonella foenumgraecum (fenugreek seeds/methi seeds) has got any preventive role against the increment in amount of connective tissue in thymic section in diabetes mellitus. Study type: an experimental study on Long Evans rats which were divided into three equal groups depending on their different sorts of dietary feeding and drug treatment. Setting: Anatomy department of the then IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in diabetes, Endocrine & Metabolic Disorders). Subjects: Fifty eight healthy young Long Evans rats of either sex weighing 72 to 174gm aged between 50 to 60 days were used in this study. Main outcome measures: variation in amount of connective tissue in thymic sections in different groups of rats. Result: in the nondiabetic control group the increased in amount of connective tissue in thymic section is lower than in diabetic control group. On the other hand, the increased in amount of connective tissue in thymic section in the fenugreek-treated diabetic rats is also lower than the amount of connective tissue in thymic section in diabetic control group but it is more or less similar to the amount of connective tissue in thymic section in nondiabetic control group. Conclusion: Fenugreek showed a tendency of acting against the increased in amount of connective tissue in thymic section in Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing fenugreek as a safe, useful effective agent to minimize the increment in amount of connective tissue in thymic section improving the diabetic condition by acting as antidiabetogenic agent. Key words: Diabetes mellitus; Connective tissue; Fenugreek; Thymus DOI: http://dx.doi.org/ 10.3329/bja.v9i1.8149 Bangladesh Journal of Anatomy January 2011, Vol. 9 No. 1 pp 49-52

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Bangladesh Journal of Anatomy

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