Formulation and Evaluation of Fast Dissolving Buccal Film containing Vildagliptin

The present study deals with the formulation of fast dissolving films of vildagliptin that is used for the treatment of Diabetes. The concept of fast dissolving drug delivery emerging from the desire to provide better patient compliance and avoid first pass metabolism. In the present research work, various trials were carried out using film forming agents such as HPMC, Maltodextrine, Polyethylene alcohol, to prepare an ideal film. Solvent casting method was used for the preparation of films. The prepared films were evaluated for weight uniformity, drug content, film thickness, folding endurance. The in vitro dissolution studies were carried out using ph-6.8 phosphate buffer. This approach increase therapeutic efficiency of pharmaceutical actives by avoiding hepatic first pass metabolism, deliver drug molecule in control manner, enhance absorption and improves patient compliance