产AmpC β-内酰胺酶和金属β-内酰胺酶肺炎克雷伯菌在利比亚塞卜哈的出现

K. Ahmad, Almahdi Ahmed Mohamed Alamen, Shamsi Abdullah Mohamd Saad, Abdelkader Alsanousi G. Elzen
{"title":"产AmpC β-内酰胺酶和金属β-内酰胺酶肺炎克雷伯菌在利比亚塞卜哈的出现","authors":"K. Ahmad, Almahdi Ahmed Mohamed Alamen, Shamsi Abdullah Mohamd Saad, Abdelkader Alsanousi G. Elzen","doi":"10.5505/ias.2019.93798","DOIUrl":null,"url":null,"abstract":"The emergence of antimicrobial resistance, especially to the β-lactam group, which is the most commonly used antibiotic to treat various infectious diseases, is particularly important because it limits the therapeutic options, thereby increasing the morbidity and mortality rates [1, 2]. In Enterobacteriaceae, antibiotic resistance is linked to different mechanisms, for example the production of a certain type of enzymes named as extended-spectrum β-lactamases (ESBLs). ESBLs are plasmid-mediated and efficiently hydrolyze penicillins, third-generation cephalosporins, and aztreonam, which are commonly used to treat infections [3, 4]. In addition, antibiotic resistance due to AmpC β-lactamases, 16S rRNA methylases, aminoglycoside-modifying enzymes, and carbapenemases has also been reported [5]. ESBL-producing bacteria remain susceptible to carbapenems, and the activity of these enzymes is inhibited by clavulanic acid [6, 7]. In K. pneumoniae, AmpC beta-lactamases are located on plasmids, while in other Enterobacteriaceae spp., these enzymes are either plasmid or chromosomally encoded [8, 9]. AmpC β-lactamases confer resistance to cephamycins (e.g., cefoxitin and cefotetan) and β-lactamase inhibitor combinations [6]. Moreover, K. pneumoniae has also been found to harbor carbapenemase enzyme (KPC), which confers resistance to carbapenems such as imipenem and meropenem [10]. The emergence of carbapenem-resistant Enterobacteriaceae spp. in general and K. pneumoniae, in particular, has become a major public health problem due to lack of effective antibiotics [11], increasing the morbidity ABSTRACT","PeriodicalId":351803,"journal":{"name":"medical journal of islamic world academy of sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Emergence of AmpC β-Lactamase– and Metallo-β-Lactamase–producing Klebsiella pneumoniae in Sebha, Libya\",\"authors\":\"K. Ahmad, Almahdi Ahmed Mohamed Alamen, Shamsi Abdullah Mohamd Saad, Abdelkader Alsanousi G. Elzen\",\"doi\":\"10.5505/ias.2019.93798\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The emergence of antimicrobial resistance, especially to the β-lactam group, which is the most commonly used antibiotic to treat various infectious diseases, is particularly important because it limits the therapeutic options, thereby increasing the morbidity and mortality rates [1, 2]. In Enterobacteriaceae, antibiotic resistance is linked to different mechanisms, for example the production of a certain type of enzymes named as extended-spectrum β-lactamases (ESBLs). ESBLs are plasmid-mediated and efficiently hydrolyze penicillins, third-generation cephalosporins, and aztreonam, which are commonly used to treat infections [3, 4]. In addition, antibiotic resistance due to AmpC β-lactamases, 16S rRNA methylases, aminoglycoside-modifying enzymes, and carbapenemases has also been reported [5]. ESBL-producing bacteria remain susceptible to carbapenems, and the activity of these enzymes is inhibited by clavulanic acid [6, 7]. In K. pneumoniae, AmpC beta-lactamases are located on plasmids, while in other Enterobacteriaceae spp., these enzymes are either plasmid or chromosomally encoded [8, 9]. AmpC β-lactamases confer resistance to cephamycins (e.g., cefoxitin and cefotetan) and β-lactamase inhibitor combinations [6]. Moreover, K. pneumoniae has also been found to harbor carbapenemase enzyme (KPC), which confers resistance to carbapenems such as imipenem and meropenem [10]. The emergence of carbapenem-resistant Enterobacteriaceae spp. in general and K. pneumoniae, in particular, has become a major public health problem due to lack of effective antibiotics [11], increasing the morbidity ABSTRACT\",\"PeriodicalId\":351803,\"journal\":{\"name\":\"medical journal of islamic world academy of sciences\",\"volume\":\"35 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medical journal of islamic world academy of sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5505/ias.2019.93798\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medical journal of islamic world academy of sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5505/ias.2019.93798","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

抗菌素耐药性的出现,特别是对治疗各种传染病最常用的抗生素β-内酰胺类抗生素的耐药性尤为重要,因为它限制了治疗选择,从而增加了发病率和死亡率[1,2]。在肠杆菌科中,抗生素耐药性与不同的机制有关,例如,一种被称为扩展谱β-内酰胺酶(ESBLs)的酶的产生。ESBLs是质粒介导的,可有效水解青霉素、第三代头孢菌素和氨曲南,这些药物通常用于治疗感染[3,4]。此外,AmpC β-内酰胺酶、16S rRNA甲基化酶、氨基糖苷修饰酶和碳青霉烯酶引起的抗生素耐药也有报道[0]。产esbl的细菌仍然对碳青霉烯类敏感,这些酶的活性被克拉维酸抑制[6,7]。在肺炎克雷伯菌中,AmpC β -内酰胺酶位于质粒上,而在其他肠杆菌科中,这些酶要么是质粒编码的,要么是染色体编码的[8,9]。AmpC β-内酰胺酶赋予对头孢霉素(如头孢西丁和头孢替坦)和β-内酰胺酶抑制剂组合[6]的耐药性。此外,肺炎克雷伯菌也被发现含有碳青霉烯酶(KPC),它赋予碳青霉烯类药物如亚胺培南和美罗培南[10]的抗性。由于缺乏有效的抗生素,耐碳青霉烯类肠杆菌科,特别是肺炎克雷伯菌的出现,已经成为一个主要的公共卫生问题,增加了发病率
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emergence of AmpC β-Lactamase– and Metallo-β-Lactamase–producing Klebsiella pneumoniae in Sebha, Libya
The emergence of antimicrobial resistance, especially to the β-lactam group, which is the most commonly used antibiotic to treat various infectious diseases, is particularly important because it limits the therapeutic options, thereby increasing the morbidity and mortality rates [1, 2]. In Enterobacteriaceae, antibiotic resistance is linked to different mechanisms, for example the production of a certain type of enzymes named as extended-spectrum β-lactamases (ESBLs). ESBLs are plasmid-mediated and efficiently hydrolyze penicillins, third-generation cephalosporins, and aztreonam, which are commonly used to treat infections [3, 4]. In addition, antibiotic resistance due to AmpC β-lactamases, 16S rRNA methylases, aminoglycoside-modifying enzymes, and carbapenemases has also been reported [5]. ESBL-producing bacteria remain susceptible to carbapenems, and the activity of these enzymes is inhibited by clavulanic acid [6, 7]. In K. pneumoniae, AmpC beta-lactamases are located on plasmids, while in other Enterobacteriaceae spp., these enzymes are either plasmid or chromosomally encoded [8, 9]. AmpC β-lactamases confer resistance to cephamycins (e.g., cefoxitin and cefotetan) and β-lactamase inhibitor combinations [6]. Moreover, K. pneumoniae has also been found to harbor carbapenemase enzyme (KPC), which confers resistance to carbapenems such as imipenem and meropenem [10]. The emergence of carbapenem-resistant Enterobacteriaceae spp. in general and K. pneumoniae, in particular, has become a major public health problem due to lack of effective antibiotics [11], increasing the morbidity ABSTRACT
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信