Yan-Ting Hsiao, Shu-Yan Chuang, Hun Hou, Yun-Chun Su, Hsiu-Cheng Yeh, Hsin-Tzu Song, Yung-Jui Chang, Wei-Yang Weng, Y. Tsai, Pin-Yu Lin, Sih-Ying Chen, Yen-Ju Lin, Mei-Wei Lin, Jun-Chau Chien
{"title":"一种采用方波伏特库伦法的CMOS/微流控芯片，用于适体体和CRISPR-Cas12a酶的生物传感","authors":"Yan-Ting Hsiao, Shu-Yan Chuang, Hun Hou, Yun-Chun Su, Hsiu-Cheng Yeh, Hsin-Tzu Song, Yung-Jui Chang, Wei-Yang Weng, Y. Tsai, Pin-Yu Lin, Sih-Ying Chen, Yen-Ju Lin, Mei-Wei Lin, Jun-Chau Chien","doi":"10.23919/VLSITechnologyandCir57934.2023.10185383","DOIUrl":null,"url":null,"abstract":"This paper presents a CMOS/microfluidics pointof-care (PoC)SoC for molecular detection using DNA aptamers and CRISPR-associated enzymes (Cas). We take advantage of the signaling property from the electron transfers of the redox reporters and present a square-wave voltcoulometry (SWVC) electrochemical readout circuit to achieve $\\gt 100\\times$ signal enhancement. The SoC is implemented in 180-nm CMOS technology, integrated with pH and temperature sensors, and consumes a total power of 2.4mW.","PeriodicalId":317958,"journal":{"name":"2023 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A CMOS/Microfluidics Point-of-Care SoC employing Square-Wave Voltcoulometry for Biosensing with Aptamers and CRISPR-Cas12a Enzymes\",\"authors\":\"Yan-Ting Hsiao, Shu-Yan Chuang, Hun Hou, Yun-Chun Su, Hsiu-Cheng Yeh, Hsin-Tzu Song, Yung-Jui Chang, Wei-Yang Weng, Y. Tsai, Pin-Yu Lin, Sih-Ying Chen, Yen-Ju Lin, Mei-Wei Lin, Jun-Chau Chien\",\"doi\":\"10.23919/VLSITechnologyandCir57934.2023.10185383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper presents a CMOS/microfluidics pointof-care (PoC)SoC for molecular detection using DNA aptamers and CRISPR-associated enzymes (Cas). We take advantage of the signaling property from the electron transfers of the redox reporters and present a square-wave voltcoulometry (SWVC) electrochemical readout circuit to achieve $\\\\gt 100\\\\times$ signal enhancement. The SoC is implemented in 180-nm CMOS technology, integrated with pH and temperature sensors, and consumes a total power of 2.4mW.\",\"PeriodicalId\":317958,\"journal\":{\"name\":\"2023 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)\",\"volume\":\"50 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2023 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23919/VLSITechnologyandCir57934.2023.10185383\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2023 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23919/VLSITechnologyandCir57934.2023.10185383","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A CMOS/Microfluidics Point-of-Care SoC employing Square-Wave Voltcoulometry for Biosensing with Aptamers and CRISPR-Cas12a Enzymes
This paper presents a CMOS/microfluidics pointof-care (PoC)SoC for molecular detection using DNA aptamers and CRISPR-associated enzymes (Cas). We take advantage of the signaling property from the electron transfers of the redox reporters and present a square-wave voltcoulometry (SWVC) electrochemical readout circuit to achieve $\gt 100\times$ signal enhancement. The SoC is implemented in 180-nm CMOS technology, integrated with pH and temperature sensors, and consumes a total power of 2.4mW.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
