Nanoscale Antimycotics and Antifungal Active Nanocomposites

Extended Abstract Fungi are simple eukaryotic organisms that are able to colonize various environments. It is estimated that there are approx. 2 million different species. Fungi have been used by people in the kitchen, brewing, viticulture, folk medicine as well as in biotechnology for the production or biotransformation of various substances and in recent years are also popular for the green synthesis of nanoparticles. Biologically active secondary metabolites of fungi have become the inspiration for the design of drug structures [1,2]. Fungi are ubiquitous in nature and are vital for the recycling of nutrients contained in organic matter (most species of fungi are saprophytes). They coexist with other organisms on the basis of mutualism, commensalism, and unfortunately parasitism [3,4]. Some fungi attack humans, animals and plants; it is estimated that 270,000 species of fungi are associated with plants and 325 are known to infect humans. Fungi cause diseases ranging from superficial and cutaneous forms through complicated subcutaneous forms to systemic (invasive fungal infections) diseases. Mycoses are caused by colonization/proliferation/sporulation of fungi in tissues and body fluids. Another type of body damage with various clinical symptoms is caused by mycotoxins, which can be ingested in the diet or secreted by fungi in the body [3-5]. It is about a people from The severity ranges from asymptomatic to mild mucocutaneous infections to life-threatening systemic infections. Approximately 10 million people have mucosal candidiasis and more than 150 million people serious fungal diseases