基因Co表达分析鉴定人肺癌调控基因

S. Hazra, Amit Kumar Shaw, Palash Das, A. Ghosh
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引用次数: 0

摘要

癌症的发生是由于基因表达水平的显著差异。像所有的癌症一样,肺癌是基因调控系统异常的结果。很明显,基因表达系统可以成功地构建表型。因此,分析共表达基因是很重要的,它可以揭示影响肿瘤形成和进化的转录调控过程的基本原理。寡核苷酸芯片和测序技术的进步使得快速监测基因在不同组织中的表达成为可能,为癌症研究领域提供了很大的机制。本文设计了一种算法,重点分析人肺表达的基因相关值,研究基因相关网络。该算法有效识别出一些与肺癌有显著关联的调控基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene Co expression analysis for identifying some regulatory genes in human lung cancer
Cancer occurs owing to significant variances in the gene expression level. Like all cancer lung cancer is the result of abnormalities in the regulatory systems of genes. It is evident that, gene expression systems can successfully frame phenotypes. Hence, it is important to analyze co expressed genes that could shed light on the fundamental principles governing the transcriptional regulatory processes influencing tumor formation and evolution. Oligonucleotide microarray and sequencing technology advancements have made it possible to quickly monitor the expression of genes in different tissues, providing a great mechanism in cancer research domain In the present article we have designed an algorithm which is focused on analyzing the gene correlation values of human lung expression and studying the gene correlation network. The algorithm effectively identifies some regulatory genes having significant association with lung cancer.
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