利用细胞光热效应和热传感器的微细胞分析装置

2009 IEEE Sensors Pub Date : 2009-10-01 DOI:10.1109/ICSENS.2009.5398235

B. Kwak, B. Kim, Suk-Heung Song, H. Cho, H. Jung

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引用次数: 0

摘要

本文介绍了一种用于分析激光诱导细胞光热效应的新型微器件，该器件采用微制铂电阻温度检测器(铂RTD)。该温度计采用微机电系统(MEMS)技术制成铂薄层，微通道采用标准软光刻技术制成聚二甲基硅氧烷(PDMS)。铂RTD的电极宽度为2µm，采用蛇形铂元件，0℃时电阻为247.88Ω。为了测量红细胞比热变化，采用532nm波长的1 ~ 300mW功率可调谐二极管泵浦固体(DPSS)激光模块。用铂RTD测量激光照射后血细胞的温度变化。利用微流控通道和流体动力聚焦对细胞进行操纵。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Micro cell analysis device using cellular photothermal effect and thermal sensor

This article presents a new micro-device for analysis of a laser-induced cellular photothermal effect using a microfabricated platinum resistance temperature detector (platinum RTD). The thermometer was fabricated with platinum thin layer using a microelectromechanical system (MEMS) technique and the microchannel was made of polydimethylsiloxane (PDMS) using a standard soft-lithography. Platinum RTD has 2µm of the electrode width with the serpentine shaped platinum element and the electric resistance at 0°C is 247.88Ω. To measure erythrocyte-specific heat variations, 1 to 300mW power tunable diode pumped solid state (DPSS) laser module was used with 532nm wavelength. Temperature variations of blood cells after laser-irradiation were measured using the platinum RTD. For manipulating the cells, a microfluidic channel and hydrodynamic focusing were used.

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2009 IEEE Sensors

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