{"title":"GLC-EMIT法测定尿中美沙酮及其主要代谢物的比较","authors":"S.D. Ferrara, L. Tedeschi, F. Castagna, M. Marigo","doi":"10.1016/S0379-0738(78)80055-3","DOIUrl":null,"url":null,"abstract":"<div><p>The enzyme-multiplied immunoassay technique (EMIT) was compared with the gas-liquid chromatographic (GLC) method in the analysis of 130 urine samples from subjects receiving methadone treatment and non-methadone controls. The GC method allowed the quantitation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, the major metabolite of methadone. A good correlation was found between the two methods. The advantages of using the EMIT system are discussed.</p></div>","PeriodicalId":75860,"journal":{"name":"Forensic science","volume":"11 3","pages":"Pages 181-188"},"PeriodicalIF":0.0000,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0379-0738(78)80055-3","citationCount":"5","resultStr":"{\"title\":\"Comparison of GLC-EMIT analysis for the assay of methadone and its major metabolite in urine\",\"authors\":\"S.D. Ferrara, L. Tedeschi, F. Castagna, M. Marigo\",\"doi\":\"10.1016/S0379-0738(78)80055-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The enzyme-multiplied immunoassay technique (EMIT) was compared with the gas-liquid chromatographic (GLC) method in the analysis of 130 urine samples from subjects receiving methadone treatment and non-methadone controls. The GC method allowed the quantitation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, the major metabolite of methadone. A good correlation was found between the two methods. The advantages of using the EMIT system are discussed.</p></div>\",\"PeriodicalId\":75860,\"journal\":{\"name\":\"Forensic science\",\"volume\":\"11 3\",\"pages\":\"Pages 181-188\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0379-0738(78)80055-3\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Forensic science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0379073878800553\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forensic science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0379073878800553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of GLC-EMIT analysis for the assay of methadone and its major metabolite in urine
The enzyme-multiplied immunoassay technique (EMIT) was compared with the gas-liquid chromatographic (GLC) method in the analysis of 130 urine samples from subjects receiving methadone treatment and non-methadone controls. The GC method allowed the quantitation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, the major metabolite of methadone. A good correlation was found between the two methods. The advantages of using the EMIT system are discussed.
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