自由生活的阿米巴脑膜脑炎:比较研究。

Q4 Medicine
Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01
A J Martínez
{"title":"自由生活的阿米巴脑膜脑炎:比较研究。","authors":"A J Martínez","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Primary amebic meningoencephalitis (PAM) is an infectious disease essentially confined to the central nervous system (CNS) and caused by free-living ameboflagellates of the genus Naegleria (N) and Acanthamoeba (A). N produces an acute fulminant, usually fatal hemorrhagic-necrotizing meningoencephalitis, associated with an inflammatory reaction composed of neutrophils, eosinophils, macrophages and a few lymphocytes. The incubation period is between 3-7 days. Typically, PAM occurs in healthy, young individuals, who frequently have a history of swimming or washing their face in infested waters. The portal of entry into the CNS is through the olfactory neuroepithelium, at the level of the cribriform plate and invasion of the amyelinic submucosal nervous plexus. Trophozoites are the only amebic forms found in the lesions. By contrast, A produces a sub-acute or chronic granulamotous meningoencephalitis (AM) with multinucleated foreign body giant cells, lymphocytes and monocytes. Cysts and trophozoites may be present in the lesions. AM have been reported in chronically ill debilitated individuals, some of them under immunosuppressive therapy, without history of recent swimming. The portal of entry into the CNS appears to be by hematogenous route. The incubation period is unknown, but perhaps more than 10 days. This comparison indicates that infection due to Naegleria produces a clearly defined clinco-pathological entity, which differs significantly from that due to Acanthamoeba, and both species of amebus should be considered in the differential diagnosis of amebic meningoencephalitis.</p>","PeriodicalId":35515,"journal":{"name":"Neurologia-Neurocirugia Psiquiatria","volume":"18 2-3 Suppl","pages":"391-401"},"PeriodicalIF":0.0000,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Free-living amebic meningoencephalitides: comparative study.\",\"authors\":\"A J Martínez\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Primary amebic meningoencephalitis (PAM) is an infectious disease essentially confined to the central nervous system (CNS) and caused by free-living ameboflagellates of the genus Naegleria (N) and Acanthamoeba (A). N produces an acute fulminant, usually fatal hemorrhagic-necrotizing meningoencephalitis, associated with an inflammatory reaction composed of neutrophils, eosinophils, macrophages and a few lymphocytes. The incubation period is between 3-7 days. Typically, PAM occurs in healthy, young individuals, who frequently have a history of swimming or washing their face in infested waters. The portal of entry into the CNS is through the olfactory neuroepithelium, at the level of the cribriform plate and invasion of the amyelinic submucosal nervous plexus. Trophozoites are the only amebic forms found in the lesions. By contrast, A produces a sub-acute or chronic granulamotous meningoencephalitis (AM) with multinucleated foreign body giant cells, lymphocytes and monocytes. Cysts and trophozoites may be present in the lesions. AM have been reported in chronically ill debilitated individuals, some of them under immunosuppressive therapy, without history of recent swimming. The portal of entry into the CNS appears to be by hematogenous route. The incubation period is unknown, but perhaps more than 10 days. This comparison indicates that infection due to Naegleria produces a clearly defined clinco-pathological entity, which differs significantly from that due to Acanthamoeba, and both species of amebus should be considered in the differential diagnosis of amebic meningoencephalitis.</p>\",\"PeriodicalId\":35515,\"journal\":{\"name\":\"Neurologia-Neurocirugia Psiquiatria\",\"volume\":\"18 2-3 Suppl\",\"pages\":\"391-401\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurologia-Neurocirugia Psiquiatria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurologia-Neurocirugia Psiquiatria","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

原发性阿米巴脑膜脑炎(PAM)是一种主要局限于中枢神经系统(CNS)的传染病,由Naegleria属阿米巴原虫(N)和棘阿米巴原虫(A)引起。阿米巴原虫可引起急性暴发性,通常是致命的出血性坏死性脑膜脑炎,伴有中性粒细胞、嗜酸性粒细胞、巨噬细胞和少量淋巴细胞组成的炎症反应。潜伏期为3-7天。通常,PAM发生在健康的年轻人身上,他们经常有在受感染的水域游泳或洗脸的历史。进入中枢神经系统的入口是通过嗅神经上皮,在筛状板水平,并侵入淀粉样粘膜下神经丛。滋养体是在病变中发现的唯一阿米巴原虫。相比之下,A产生亚急性或慢性肉芽肿性脑膜脑炎(AM),伴多核异物巨细胞、淋巴细胞和单核细胞。病变中可出现囊肿和滋养体。慢性衰弱的个体中有AM的报道,其中一些正在接受免疫抑制治疗,最近没有游泳史。进入中枢神经系统的入口似乎是通过血液途径。潜伏期不详,但可能超过10天。这一比较表明,由纳格里亚原虫引起的感染产生了一个明确的临床病理实体,这与由棘阿米巴引起的感染有明显的不同,在阿米巴脑膜脑炎的鉴别诊断中应考虑这两种阿米巴原虫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Free-living amebic meningoencephalitides: comparative study.

Primary amebic meningoencephalitis (PAM) is an infectious disease essentially confined to the central nervous system (CNS) and caused by free-living ameboflagellates of the genus Naegleria (N) and Acanthamoeba (A). N produces an acute fulminant, usually fatal hemorrhagic-necrotizing meningoencephalitis, associated with an inflammatory reaction composed of neutrophils, eosinophils, macrophages and a few lymphocytes. The incubation period is between 3-7 days. Typically, PAM occurs in healthy, young individuals, who frequently have a history of swimming or washing their face in infested waters. The portal of entry into the CNS is through the olfactory neuroepithelium, at the level of the cribriform plate and invasion of the amyelinic submucosal nervous plexus. Trophozoites are the only amebic forms found in the lesions. By contrast, A produces a sub-acute or chronic granulamotous meningoencephalitis (AM) with multinucleated foreign body giant cells, lymphocytes and monocytes. Cysts and trophozoites may be present in the lesions. AM have been reported in chronically ill debilitated individuals, some of them under immunosuppressive therapy, without history of recent swimming. The portal of entry into the CNS appears to be by hematogenous route. The incubation period is unknown, but perhaps more than 10 days. This comparison indicates that infection due to Naegleria produces a clearly defined clinco-pathological entity, which differs significantly from that due to Acanthamoeba, and both species of amebus should be considered in the differential diagnosis of amebic meningoencephalitis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Neurologia-Neurocirugia Psiquiatria
Neurologia-Neurocirugia Psiquiatria Psychology-Clinical Psychology
CiteScore
0.10
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信