N. M. Petryk, S. Yastremska
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摘要

由于William Houston, Magnus Falconar, Julian Evans的研究,我们知道脾脏具有强大的免疫保护作用,能够合成体液免疫因子,它是排毒,再动员铁的器官,并参与造血。然而,在所有的功能中,脾的造血功能尚未得到充分的探索。这是因为大多数科学家认为,髓外造血(EMH)是与骨髓功能衰竭相关的病理状态的一种表现,因为从生理上讲,它在胚胎发育时期后完全停止,在胚胎后时期几乎是不特有的。这一过程涉及骨髓腔外成熟血细胞的产生。EMH常见于骨髓纤维化、骨髓增生性疾病和血红蛋白病患者,特别是地中海贫血和镰状细胞性贫血患者。参与EMH的外周造血的关键器官是脾脏、肝脏和淋巴结。目前对有效市场假说的基本过程和机制的研究还不够。本文以实验血液学出版物为基础,对现代EMH研究进行了分析。在分析过程中,确定了进一步研究的前景方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ДОСЯГНЕННЯ ДОСЛІДЖЕННЯ ЕКСТРАМЕДУЛЯРНОГО ГЕМАТОПОЕЗУ В СЕЛЕЗІНЦІ
Thanks to the researches by William Houston, Magnus Falconar, Julian Evans we know that the spleen has powerful immune protection, is able to synthesize humoral immunity factors, it is the organ of detoxification, re-mobilization of iron, and it is involved in hemopoiesis. However, among all of functions, the hemopoietic function of the spleen still not fully explored. This is due to the fact that the extemedular hematopoiesis (EMH) is considered by most scientists as a manifestation of the pathological condition related to the failure of the bone marrow function, because physiologically, it completely stops after the embryonic development period and is almost uncharacteristic for the post-embryonic period. This process involves the production of mature blood cells outside the medullary bone cavity. EMH is often observed in patients with myelofibrosis, myeloproliferative disorders and hemoglobinopathy, especially with thalassemia and sickle cell anemia. The key organs of peripheral hematopoiesis that participate in EMH are spleen, liver and lymph nodes.Today there are not enough researches on the fundamental processes and the very mechanism of EMH. The article presents an analysis of modern EMH researches based on publications on experimental hematology. During the analysis, prospective directions for further research were identified.
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