The effect of intra-operative paracetamol on post operative pain, nausea and vomit in children who underwent adenotonsillectomy

Materials and Methods: The study included 28 children between 6 and 12 years of age and ASA classification I and II, who were scheduled for tonsillectomy or adenotonsillectomy. Patients who were administered NSAIDs within 8 hours, any analgesics within 12 hours and corticosteroids during the last 7 days pre-op were excluded from the study. No narcotic analgesics were used as pre-medication and peroperatively on the subjects. Anesthesia was induced by Thiopental 5 mg/kg i.v. and muscle paralysis by Rocuronium 0.1 mg/kg i.v. Anesthetic permanence was achieved by Sevoflurane 1-2 % and N2O/O2 50 %/50 %. The subjects were randomized in two separate groups. Group P was administered (Paracetamol, n=14) paracetamol 30 mg/kg i.v. and Group S (Saline, n=14) was administered saline infusion in equivalent volume at minute 15 peroperatively. The nausea-vomit frequency was recorded post-operatively at 15 minute intervals using post-op nauseavomit scoring while the pain score was recorded using the 7 point facial expression scale.