计算RNA结构的参数排列:可视化和实践

Wangsen Feng, Bei Zhang, Lusheng Wang
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引用次数: 0

摘要

RNA结构比对在生物学研究中非常重要。与成对序列比对类似,在比较两个RNA结构时,对于如何确定匹配、错配、索引和间隙的权重经常存在分歧。在这里,我们开发了一个可视化工具,用于计算两个RNA结构的参数对齐。使用该工具,用户可以清楚、完整地看到参数选择对RNA结构最优排列的影响。该软件可用于学术用途(http://www.cs.cityu.edu.hk/~lwang/software/ParaRNA/)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computing Parametric Alignment of RNA Structures: Visualization and Practice
Alignment of RNA structures is very important in biological research. Similar to pair-wise sequence alignment, there is often disagreement about how to weight matches, mismatches, indels and gaps when comparing two RNA structures. Here, we develop a visual tool for computing parametric alignment of two RNA structures. With this tool, users can see explicitly and completely the effect of parameter choices on the optimal alignments of RNA structures. The software is available for academic use ( http://www.cs.cityu.edu.hk/~lwang/software/ParaRNA/).
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