Тhe NiO纳米颗粒吸入毒性的实验评估

M. Sutunkova
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引用次数: 1

摘要

介绍。镍和合金钢的冶金生产(电焊中使用)中,镍纳米颗粒污染了工作场所的空气。NiO纳米颗粒的毒性在一些实验中得到了研究,但其毒性作用的机制尚不清楚,需要更广泛的实验数据基础。研究NiO纳米颗粒慢性吸入暴露的毒性作用。材料和方法。本研究采用浓度为0.2±0.01 mg/m3的“单鼻”装置,对远交系雌性大鼠重复低剂量吸入纯度为99.99%的NiO纳米颗粒,浓度为23±5 nm,每天4小时,每周5天,持续10个月。为确定该浓度,初步中试试验采用浓度为1.00±0.12 mg/m3的5倍暴露。NiO纳米颗粒短期和慢性吸入暴露会影响脂质过氧化、红细胞参数、肝肾功能和氧化还原平衡。慢性吸入实验中,三种物质均引起肺泡吞噬反应活跃,嗜中性粒细胞与肺泡巨噬细胞的关系及支气管肺泡灌洗液中酶的水平均证实了它们的高细胞毒性。结论:0.2 mg/m3浓度的nio纳米颗粒吸入对实验动物产生中度毒性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Тhe experimental assessment of NiO nanoparticles toxicity in inxalation exposure
Introduction.Nanoparticles of NiO pollute air of workplace in metallurgic production of nickel and alloyed steel (during their use in electric welding). Toxicity of NiO nanoparticles was studied in some experiments, but mechanisms underlying their toxic eff ects are not understood and require wider base of experimental data.Objective. To study toxic eff ects of NiO nanoparticles in chronic inhalation exposure.Materials and methods.Outbred female rats were subjected to repeated low-level inhalation exposure to NiO nanoparticles of 99.99% purity, measured 23±5 nm, 4 hours per day, 5 days per week, up to 10-month duration in an “only nose” device with concentration 0.2±0.01 mg/m3. To select this concentration, preliminary pilot experiment included 5-fold exposure with concentration 1.00±0.12 mg/m3.Results.NiO nanoparticles in short-term and chronic inhalation exposure aff ect lipids peroxidation, red blood parameters, liver and kidney functions, oxidation-reduction balance. All three terms of chronic inhalation experiment cause active alveolar phagocytosis reaction, and their high cytotoxicity is proved by relation of neutrophils to alveolar macrophages and by enzymes levels in bronchoalveolar lavage.Conclusions.NiO nanoparticles if inhaled in concentration 0.2 mg/m3 cause moderate toxic eff ect in experimental animals.
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