{"title":"脑深部刺激治疗难治性抑郁症:预测反应和优化治疗","authors":"Susan K. Conroy , Paul E. Holtzheimer","doi":"10.1016/j.pmip.2019.10.002","DOIUrl":null,"url":null,"abstract":"<div><p><span>Depression has been increasingly recognized as a systems-level disorder; thus, treatments that target critical brain regions in order to influence the function of brain circuits are an important area of study. </span>Deep brain stimulation<span><span> (DBS), a therapeutic modality initially used in </span>movement disorders, was first applied to treatment-resistant depression (TRD) in 2005. Multiple groups around the world have treated several hundred TRD patients with DBS on an investigational basis. There is no current single accepted protocol for DBS in TRD; variation is possible both in anatomic site and stimulation parameters. The purpose of this article is to discuss the current state of knowledge for DBS in TRD as it relates to patient selection, anatomic target selection and optimization, and stimulation parameters.</span></p></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"17 ","pages":"Pages 43-45"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmip.2019.10.002","citationCount":"1","resultStr":"{\"title\":\"Deep brain stimulation for treatment-resistant depression: Predicting response and optimizing treatment\",\"authors\":\"Susan K. Conroy , Paul E. Holtzheimer\",\"doi\":\"10.1016/j.pmip.2019.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Depression has been increasingly recognized as a systems-level disorder; thus, treatments that target critical brain regions in order to influence the function of brain circuits are an important area of study. </span>Deep brain stimulation<span><span> (DBS), a therapeutic modality initially used in </span>movement disorders, was first applied to treatment-resistant depression (TRD) in 2005. Multiple groups around the world have treated several hundred TRD patients with DBS on an investigational basis. There is no current single accepted protocol for DBS in TRD; variation is possible both in anatomic site and stimulation parameters. The purpose of this article is to discuss the current state of knowledge for DBS in TRD as it relates to patient selection, anatomic target selection and optimization, and stimulation parameters.</span></p></div>\",\"PeriodicalId\":19837,\"journal\":{\"name\":\"Personalized Medicine in Psychiatry\",\"volume\":\"17 \",\"pages\":\"Pages 43-45\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.pmip.2019.10.002\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Personalized Medicine in Psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468171719300134\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized Medicine in Psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468171719300134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Deep brain stimulation for treatment-resistant depression: Predicting response and optimizing treatment
Depression has been increasingly recognized as a systems-level disorder; thus, treatments that target critical brain regions in order to influence the function of brain circuits are an important area of study. Deep brain stimulation (DBS), a therapeutic modality initially used in movement disorders, was first applied to treatment-resistant depression (TRD) in 2005. Multiple groups around the world have treated several hundred TRD patients with DBS on an investigational basis. There is no current single accepted protocol for DBS in TRD; variation is possible both in anatomic site and stimulation parameters. The purpose of this article is to discuss the current state of knowledge for DBS in TRD as it relates to patient selection, anatomic target selection and optimization, and stimulation parameters.
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