一种基于人工纤毛的微型混合器，用于卓越的斑马鱼精子激活

2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS) Pub Date : 2017-02-23 DOI:10.1109/MEMSYS.2017.7863641

Chia‐Yuan Chen, Pin Y. Huang, Bivas Panigrahi

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引用次数: 0

摘要

本研究的目的是提出一种基于人工纤毛的微流控装置，通过控制人工纤毛跳动对斑马鱼精子产生的流体动力学诱导，实现对斑马鱼精子的有效激活。通过该装置可以精确控制对精子激活成功与否有重要影响的流体剪切大小。精子活化率的绝对值为70%，平均值为65%，差异有统计学意义(p值< 0.05)。本设计将通过微流控平台显著推进精子激活的实践。

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An artificial cilia based micromixer for superior zebrafish sperm activation

The objective of this study is to propose an artificial cilia based microfluidic device for efficient activation of zebrafish sperm by controlling the hydro-dynamics induced on the zebrafish sperm from the artificial cilia beating. The magnitude of fluid shear which has significant effect on the success of sperm activation was precisely controlled through this proposed device. A superior sperm activation of an absolute value of 70% with an average value of 65 % was achieved with a statistical significance (p-value < 0.05). The present design will advance the practice of the sperm activation significantly through the microfluidic platform.

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2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)

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