评估一种多光谱漫射光谱学装置,用于评估与心脏代谢风险相关的身体成分改变

Z. Marcinkevics, K. Volceka, L. Ozoliņa-Moll, J. Zaharans
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引用次数: 0

摘要

心血管代谢疾病包括导致心血管疾病和糖尿病风险增加的一系列疾病。随着人口超重比例的增加,当多余的脂肪组织变成恶性时,诊断是很重要的。需要开发一种安全、可移动、无创的方法,这种方法操作简单、成本低,同时也能准确评估瘦人和肥胖者的皮下脂肪组织(SAT)。利用光学方法在体内测量SAT的原型装置已经被开发出来,它包含多个四个波长(660nm, 780nm, 870nm, 940nm)的led,分布在距离光电探测器不同的距离上,允许不同的光穿透深度进入皮下组织。5名年轻健康的女学生参与了研究;测量在三个身体部位进行:小腿,上腹和下腹。将原型机获得的背向散射光与高分辨率超声成像测量的SAT进行了比较。变异系数表明测量结果具有较高的可靠性。统计学意义显著(r=0.81 ~ r=0.95;p<0.05),四个波长的背散射光强度与SAT厚度之间存在相关性,特别是在源-探测器距离为25mm时。这种新型装置原型有可能成为传统SAT测量和心脏代谢风险评估的一个很好的替代方案。多光谱方法可以潜在地提高SAT测定的精度和空间分辨率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of a multispectral diffuse optical spectroscopy device for assessment of cardiometabolic risk related alterations of body composition
Cardiometabolic diseases encompass a combination of conditions which lead to an increase in the risk of cardiovascular disease and diabetes. With the increasing percentage of the population becoming overweight, it is important to diagnose when the excess adipose tissue becomes malign. The development of a safe, mobile, non-invasive method that would be easy to perform, and low-cost, but also would offer an accurate assessment of subcutaneous adipose tissue (SAT) both in lean and in obese persons is required. A prototype device using an optical method for measurement of the SAT in vivo has been developed, it contains multiple LEDs with four wavelengths (660nm, 780nm, 870nm, 940nm) distributed at various distances from the photodetector which allow different light penetration depths into the subcutaneous tissue. Five young healthy female students participated in the study; the measurements were performed on three body sites: calf, upper and lower abdomen. The backscattered light acquired with the prototype was compared to SAT measured with high resolution ultrasound imaging. The coefficient of variation indicated high reliability of the measurements. Statistically significant (from r=0.81 to r=0.95; p<0.05) correlation between intensity of backscattered light and SAT thicknesses for all four wavelength was observed, especially at source-detector distance 25mm. The novel device prototype has a potential to be a good alternative for conventional SAT measurement and assessment of cardiometabolic risk. Amultispectral approach can potentially increase precision and spatial resolution of SAT determination.
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