{"title":"紫外线激光刺激激活hNT星形胶质细胞2×2网络","authors":"Si Li, M. Simpson, E. S. Graham, C. Unsworth","doi":"10.1109/NER.2019.8717185","DOIUrl":null,"url":null,"abstract":"To further investigate the communication in astrocytic networks, in vitro astrocytes were patterned in simple networks by using parylene-C/SiO2 platform. We designed a 2×2 small network on parylene-C/SiO2 platform and demonstrated, for the first time, that the intracellular calcium response of a single human hNT astrocyte stimulated by UV laser pulses can be transmitted to neighboring astrocytes in this 2×2 small network. The calcium responses of the astrocytes network were recorded and analyzed.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Activating a 2×2 Network of hNT Astrocytes with UV Laser Stimulation\",\"authors\":\"Si Li, M. Simpson, E. S. Graham, C. Unsworth\",\"doi\":\"10.1109/NER.2019.8717185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To further investigate the communication in astrocytic networks, in vitro astrocytes were patterned in simple networks by using parylene-C/SiO2 platform. We designed a 2×2 small network on parylene-C/SiO2 platform and demonstrated, for the first time, that the intracellular calcium response of a single human hNT astrocyte stimulated by UV laser pulses can be transmitted to neighboring astrocytes in this 2×2 small network. The calcium responses of the astrocytes network were recorded and analyzed.\",\"PeriodicalId\":356177,\"journal\":{\"name\":\"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)\",\"volume\":\"46 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/NER.2019.8717185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NER.2019.8717185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
为了进一步研究星形胶质细胞网络中的通讯，利用聚苯乙烯- c /SiO2平台对体外星形胶质细胞进行了简单网络的建模。我们在聚苯乙烯- c /SiO2平台上设计了一个2×2小网络，首次证明了紫外激光脉冲刺激单个人类hNT星形胶质细胞的细胞内钙反应可以在这个2×2小网络中传递给邻近的星形胶质细胞。记录并分析星形胶质细胞网络对钙离子的反应。
Activating a 2×2 Network of hNT Astrocytes with UV Laser Stimulation
To further investigate the communication in astrocytic networks, in vitro astrocytes were patterned in simple networks by using parylene-C/SiO2 platform. We designed a 2×2 small network on parylene-C/SiO2 platform and demonstrated, for the first time, that the intracellular calcium response of a single human hNT astrocyte stimulated by UV laser pulses can be transmitted to neighboring astrocytes in this 2×2 small network. The calcium responses of the astrocytes network were recorded and analyzed.
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