FXR mediated bile acid signal to advance the study of cirrhosis of the liver regeneration

To explore the mechanism of FXR mediated bile acid signal to cirrhosis of the liver regeneration. The total sample size of 75 male SD rats were randomly divided equally into 3 groups i.e., 25 samples in each group. The three groups were cholic acid deficiency group, cholic acid load group and control group. Cholic acid load group of forage feed 0.2% cholic acid, cholic acid deficiency group feeding to enamine with 2%, the control to the fed standard feed. Liver body ratio, AST, and ALT, HGF levels, liver specimens, protein levels of There were no significant differences in ALT, AST and HGF levels among the three groups at the end of surgery (P>0.05), but from the 3rd day after surgery, ALT, and AST levels in the cholic acid-deficient group were higher than those in the cholic acid-loaded group and the control group, while HGF levels were lower than those in the cholic acid-loaded group and the control group (P<0.05).