Experimental studies of humoral factors of inflammation and regeneration in patients with injuries of the fronto-basal region

Materials and methods: Under the conditions of the experiment, the authors conducted research of mononuclear blood cultures were on the identification of сytokine factors of inflammation and regeneration in patients with frontal bone trauma (29 patients) and practically healthy donors (11 persons). Factors of inflammation (interleukin-1β, γ-interferon), anti-inflammation and regeneration (interleukin-34 and transforming growth factor – TGF-1β) were determined in the blood serum by ELISA, under the influence of medications that remodulate bone matrix and regeneration – osteogenon and soluble vitamin D3. Results and conclusions: It was found that the osteogenon and aquadetrim (vit. D3) have a positive influence on the production of cytokines by blood mononuclears of the patients with FBT: they both decrease the level of production of inflammatory cytokines in vitro and increase the level of production of anti-inflammatory cytokines especially when used together. The received data prove the expediency of including osteogenon and aquadetrim in to the complex treatment of patients with frontal bone trauma.