MODELS OF PARKINSON'S DISEASE IN THE LABORATORY ANIMALS

The increase in the incidence of Parkinson's disease, due to the aging population, is an acute medical and social problem. For a deeper understanding of the pathogenesis of the disease and ways to pre-vent it or pharmacological correction, numerous preclinical studies in animals are needed. The re-view presents the classification of modern models of Parkinson's disease in laboratory animals, the prevalence of use and their pathophysiological mechanisms. Rodents, non-human primates, and some non-mammals are used to model of Parkinson's disease; models can be neurotoxic or genetic in origin. Conclusions were drawn about the translational potential of each model, the possibility of using it for studying pathogenesis or therapy, as well as the complexity of application for researchers.