Magnesium Supplementation Effect On Muscle Magnesium Content And Magnesium Loss In Humans During Hypokinesia

Objective: To study the impact of magnesium (Mg) supplementation on muscle Mg content and muscle Mg loss during hypokinesia (HK; diminished movement). Methods: This study was conducted on 40 physically healthy male volunteers during a pre-experimental period of 30 days and an experimental period of 364 days. Subjects were equally divided into four groups: unsupplemented control subjects (UCS), unsupplemented experimental subjects (UES), supplemented control subjects (SCS), and supplemented experimental subjects (SES). A daily supplementation of 3.0 mmol of magnesium-chloride per kg body weight was given to the subjects in the SCS and SES groups. Results: The muscle Mg content decreased (p<.05) and plasma Mg concentration, and Mg loss in urine and feces increased (p<.05) in the SES and UES groups compared to their pre-experimental levels and the values in their respective control groups (SCS and UCS).The muscle Mg content decreased (p<.05) more, and plasma Mg concentration, and Mg loss in urine and feces increased more (p<.05) in the SES group than in the UES group. Conclusion: It is concluded that muscle Mg content is not decreased by the Mg deficient diet and bodily Mg loss is not increased by the higher muscle Mg content but due to the inability of the body to use Mg; this is because muscle Mg level cannot reduce with Mg supplements and Mg loss cannot increase with muscle Mg deficiency unless Mg deposition decreases.