Antimicrobial Resistance Patterns of Pseudomonas aeruginosa in a Vietnamese Tertiary Care Hospital

Background: Vietnam is one of the countries at high alert of antibiotic resistance. This study aimed to evaluate the antimicrobial susceptibility of P. aeruginosa isolates collected from a Vietnamese hospital in 2019. Methods: A retrospective review was conducted of all reports of P. aeruginosa isolates from the records of the laboratory of Nhan Dan Gia Dinh Hospital between January 01 2019 to December 31 2019. Results: Of 224 samples, the most common infection from which P. aeruginosa was isolated was pneumonia in hospitalized patients (49.1%) followed by skin and skin-structure infections (19,6%), and intra-abdominal infections (18.8%). The rates of isolates with MDR, XDR, and PDX were 7.1%, 20.5%, and 0.0%. Colistin was the most active agent overall (100.0%). Amikacin was the second most active agent, inhibiting 78.9% of all isolates. Other commonly used antipseudomonal β-lactams (cefepime, ceftazidime, imipenem, meropenem, and piperacillin-tazobactam) had susceptibilities for all isolates ranging from 68.0% to 70.9%. Ciprofloxacin and levofloxacin had overall 64.0%S and 61.8%S, respectively. Ticarcillin/Clavulanic acid was the least active antimicrobial tested with overall susceptibility of 38.1%. results highlight the of in infections and require urgent antibiotic stewardship programs effectively.