服用贯叶连翘提取物改善男性射精控制和性满意度的初步研究

T. Cannon-Smith, J. Kaufman
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引用次数: 8

摘要

最常见的男性性功能障碍是早泄(PE),但目前还没有批准的有效治疗方法。基于对天然补品贯叶连翘(Hypericum perforatum)在PE大鼠模型中延迟射精的药理学研究,我们通过阴道内射精潜伏期(IELT)和性满意度来评估贯叶连翘提取物对射精反射持续时间的影响。16名渴望更长的性交时间且无勃起功能障碍的男性在性活动前立即服用贯叶连翘。在2周和整个4周的研究期间,使用性交日记记录基线数据。参与者被要求在治疗前后用秒表测量雅思成绩,并完成性功能问卷调查。16例受试者均完成研究(平均年龄35.0±4.6岁)。受试者的平均雅思考试时间从246±29秒显著增加到331±34秒(p<0.002)。16名男性中有14名(87.5%)报告了雅思成绩的改善。在那些认为体育锻炼令人烦恼的男性和那些认为体育锻炼对他们来说不是问题的男性中,这种情况都有所增加。男性满意度由3.8±0.27分提高到4.25±0.21分(p<0.03)。女性满意度得分也由4.9±0.27分显著提高到5.2±0.23分(p<0.04)。这项初步研究因缺乏安慰剂对照而受到限制。没有对勃起功能或性高潮产生系统性或不良影响的报道。贯叶连翘(Hypericum perforatum)提取物可延长性交时间,提高有或无PE症状男性的性满意度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improved Ejacultory Control And Sexual Satisfaction In Pilot Study Of Men Taking Hypericum Perforatum Extract
The most common male sexual dysfunction is premature ejaculation (PE) and yet there are no approved currently effective therapies. Based on research that Hypericum perforatum, a natural supplement has been demonstrated pharmacologically to delay ejaculation in a rat model of PE, we evaluated the effects of hyperforin extract of Hypericum perforatum on the ejaculatory reflex duration by using the intravaginal ejaculatory latency time (IELT) and sexual satisfaction. Sixteen men who desired longer sexual intercourse and without erectile dysfunction were treated with Hypericum perforatum immediately prior to sexual activity. An intercourse diary was used to document baseline data for 2 weeks and throughout the study period of 4 weeks. Partners were asked to measure IELT using a stopwatch as well as complete a sexual function questionnaire both pre and post treatment. All 16 subjects completed the study (average age 35.0 ± 4.6 years old). There was a significant increase in mean IELT times from 246±29 to 331±34 seconds (p<0.002) in subjects taking hyperforin extract. Fourteen of 16 men (87.5%) reported an improvement in IELT. The increase was seen in both the men who reported PE as bothersome and those who did not feel that PE was a problem for them. There was also significant increase in male satisfaction scores from 3.8±0.27 to 4.25 ±0.21 (p<0.03). Female satisfaction scores also showed a significant increase from 4.9±0.27 to 5.2±0.23 (p<0.04). This pilot study was limited by the lack of placebo control. No systemic or adverse effects on erectile function or orgasm were reported. Hyperforin extract of Hypericum perforatum can increase the duration of sexual intercourse and improve sexual satisfaction for men with and without complaints of PE.
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