Covid-19大流行期间耐氟喹诺酮类肺炎克雷伯菌临床分离株的细菌学特征

M. Abdulakreem, N. Yassin.
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引用次数: 1

摘要

由于多药耐药菌株的出现,肺炎克雷伯菌感染的治疗变得更加困难。氟喹诺酮类药物被广泛用于治疗由不同细菌引起的呼吸道感染和尿路感染。因此,本研究旨在评估伊拉克杜胡克省各种临床样本中的氟喹诺酮类药物耐药性并检测ESBL生产者。采用常规微生物学方法从不同临床标本中鉴定出肺炎克雷伯菌。此外,采用KirbyBauer圆盘扩散法检测抗生素敏感性。120株肺炎克雷伯菌分离株中,引起尿路感染的占73.3%,女性占74.2%,男性占25.8%;120株分离株中,门诊患者分离株占76.7%,住院患者分离株占23.3%。尿样中对环丙沙星、左氧氟沙星、诺氟沙星、氧氟沙星的耐药率分别为52.5%、36.7%、33.3%、33.3%,对萘啶酸耐药率为22.5%。120份样品中,仅有12株呈高粘滞性。约25%的环丙沙星耐药和17.5%的左氧氟沙星耐药同时为ESBL生产者。根据本研究,肺炎克雷伯菌对诺氟沙星、氧氟沙星和钠利地酸的敏感性高于环丙沙星和左氧氟沙星。此外,本研究建立了ESBL与氟喹诺酮类药物耐药性之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacteriological Characterization of Fluoroquinolones-Resistant Klebsiella pneumoniae Clinical Isolates During Covid-19 Pandemic
The treatment of Klebsiella pneumoniae infections has become more difcult due to the emergence of multidrug-resistant strains. Fluoroquinolones have been widely used to treat respiratory tract infections and urinary tract infections caused by different bacteria. Therefore, this study aimed to evaluate fluoroquinolones resistance and detect ESBL producers in various clinical samples in Duhok Province, Iraq. K. pneumoniae was identied from different clinical samples by conventional microbiological tests. In addition, antibiotic susceptibility was detected by the KirbyBauer disc diffusion method. Out of 120 K. pneumoniae isolates, 73.3% were causing urinary tract infections, in most cases, 74.2% were among females and 25.8% among males, and among those 120 isolates, 76.7% of isolates were from outpatients, and 23.3% were inpatients. The resistance rate among all samples was 52.5%, 36.7%, 33.3%, 33.3%, ciprofloxacin, levofloxacin, norfloxacin, and ofloxacin, respectively in urine samples, the resistance to nalidixic acid was 22.5%. Among 120 samples, only 12 isolates were hypermucoviscosity. About 25% of ciprofloxacin and 17.5% of levofloxacin resistances were ESBL producers simultaneously. According to this study, K. pneumoniae is more susceptible to norfloxacin, ofloxacin, and nalidixic acid than ciprofloxacin and levofloxacin. Additionally, this study establishes a link between ESBL and fluoroquinolone resistance.
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