Shu-Ting Chang, Yung-Hsiang Lin, Chen-Meng Kuan, K. Kan, Yung-Kai Lin
{"title":"抗衰老胶原蛋白配方","authors":"Shu-Ting Chang, Yung-Hsiang Lin, Chen-Meng Kuan, K. Kan, Yung-Kai Lin","doi":"10.18178/ijpmbs.9.4.175-179","DOIUrl":null,"url":null,"abstract":"—This article demonstrates the synergistic effect of a collagen formula drink on improvement in Extracellular Matrix (ECM) protein synthesis and down-regulation of the collagen degradation gene and Reactive Oxygen Species (ROS) formation in human fibroblasts. The collagen formula drink mainly consists of porcine and fish collagens, which is an uncommon approach to skin repair and anti-aging. The collagen formula drink could enhance the collagen and elastin formation in UVA-treated CCD-966SK cells by 30% and 19%, respectively. In addition, it up-regulated collagen- and hyaluronate (HA)-associated genes ( COL1A1 , COL1A2 , LOX , and HAS2 ) in the range of 75%-187% as well as down-regulated collagen-degradation gene (MMP-1) by 41%. Also, the collagen formula drink lowered the ROS formation in CCD-966SK cells by 26%. Accordingly, the collagen formula drink can substantially improve the skin repair efficiency after photodamage and provide a comprehensive protection effect on anti-aging.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Collagen Formula for Anti-aging\",\"authors\":\"Shu-Ting Chang, Yung-Hsiang Lin, Chen-Meng Kuan, K. Kan, Yung-Kai Lin\",\"doi\":\"10.18178/ijpmbs.9.4.175-179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"—This article demonstrates the synergistic effect of a collagen formula drink on improvement in Extracellular Matrix (ECM) protein synthesis and down-regulation of the collagen degradation gene and Reactive Oxygen Species (ROS) formation in human fibroblasts. The collagen formula drink mainly consists of porcine and fish collagens, which is an uncommon approach to skin repair and anti-aging. The collagen formula drink could enhance the collagen and elastin formation in UVA-treated CCD-966SK cells by 30% and 19%, respectively. In addition, it up-regulated collagen- and hyaluronate (HA)-associated genes ( COL1A1 , COL1A2 , LOX , and HAS2 ) in the range of 75%-187% as well as down-regulated collagen-degradation gene (MMP-1) by 41%. Also, the collagen formula drink lowered the ROS formation in CCD-966SK cells by 26%. Accordingly, the collagen formula drink can substantially improve the skin repair efficiency after photodamage and provide a comprehensive protection effect on anti-aging.\",\"PeriodicalId\":281523,\"journal\":{\"name\":\"International Journal of Pharma Medicine and Biological Sciences\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharma Medicine and Biological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18178/ijpmbs.9.4.175-179\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharma Medicine and Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18178/ijpmbs.9.4.175-179","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
—This article demonstrates the synergistic effect of a collagen formula drink on improvement in Extracellular Matrix (ECM) protein synthesis and down-regulation of the collagen degradation gene and Reactive Oxygen Species (ROS) formation in human fibroblasts. The collagen formula drink mainly consists of porcine and fish collagens, which is an uncommon approach to skin repair and anti-aging. The collagen formula drink could enhance the collagen and elastin formation in UVA-treated CCD-966SK cells by 30% and 19%, respectively. In addition, it up-regulated collagen- and hyaluronate (HA)-associated genes ( COL1A1 , COL1A2 , LOX , and HAS2 ) in the range of 75%-187% as well as down-regulated collagen-degradation gene (MMP-1) by 41%. Also, the collagen formula drink lowered the ROS formation in CCD-966SK cells by 26%. Accordingly, the collagen formula drink can substantially improve the skin repair efficiency after photodamage and provide a comprehensive protection effect on anti-aging.
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