G. Di Domenico, G. Zavattini, E. Moretti, A. Piffanelli, M. Giganti, A. Motta, N. Sabba, L. Uccelli, E. Benini, A. Duatti, C. Bolzati, A. Boschi, A. Del Guerra
{"title":"定量YAP-(S)PET小动物扫描仪:初步结果","authors":"G. Di Domenico, G. Zavattini, E. Moretti, A. Piffanelli, M. Giganti, A. Motta, N. Sabba, L. Uccelli, E. Benini, A. Duatti, C. Bolzati, A. Boschi, A. Del Guerra","doi":"10.1109/NSSMIC.2001.1008639","DOIUrl":null,"url":null,"abstract":"We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with /sup 99m/Tc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.","PeriodicalId":159123,"journal":{"name":"2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)","volume":"352 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2001-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Quantitative YAP-(S)PET small animal scanner: preliminary results\",\"authors\":\"G. Di Domenico, G. Zavattini, E. Moretti, A. Piffanelli, M. Giganti, A. Motta, N. Sabba, L. Uccelli, E. Benini, A. Duatti, C. Bolzati, A. Boschi, A. Del Guerra\",\"doi\":\"10.1109/NSSMIC.2001.1008639\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with /sup 99m/Tc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.\",\"PeriodicalId\":159123,\"journal\":{\"name\":\"2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)\",\"volume\":\"352 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/NSSMIC.2001.1008639\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NSSMIC.2001.1008639","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Quantitative YAP-(S)PET small animal scanner: preliminary results
We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with /sup 99m/Tc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.
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