毫米波和高频下真实角化细胞模型的微剂量测定

Zain Haider, Y. Drean, R. Sauleau, L. Caramazza, M. Liberti, M. Zhadobov
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引用次数: 0

摘要

毫米波(mmWave)和无线电力传输(WPT)技术的广泛传播为生物电磁相互作用的表征带来了新的挑战。本研究的目的是定量研究分别在6.78 MHz和60 GHz的细胞内对这种电磁辐射的诱导。一个现实模型的角质细胞,其中考虑到复杂的形态和细胞器的体积分数,被开发。采用有限元法求解拟静态近似下的拉普拉斯方程。结果表明,由于膜的屏蔽作用减弱,胞室和亚胞室内的功率损耗密度随频率增加而增加。在60 GHz和6.78 MHz时,细胞和亚细胞细胞器内的平均功率损失密度(PLDavg)比1 kHz时分别高出6和3个数量级。此外,与细胞质(CP)内的背景PLDavg相比,通过核孔(Np)的细胞内流量在6.78 MHz时的暴露水平高出3个数量级,在60 GHz时的暴露水平高出2.5倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microdosimetry in a realistic keratinocyte cell model at mmWave and HF frequencies
Wide spread of millimeter-wave (mmWave) and wireless power transfer (WPT) technologies opens new challenges in terms of characterization of bioelectromagnetic interactions. The objective of this study is to investigate quantitatively the induction of such electromagnetic radiation within cells at 6.78 MHz and 60 GHz respectively. A realistic model of the keratinocyte, which takes into account the complex morphologies and volume fraction of organelles, was developed. The finite element method (FEM) was used to solve the Laplace’s equation under quasi-static approximation. The results show that the power loss density (PLD) within the cellular and subcellular compartments increases with frequency due to diminished shielding effect of the membranes. At 60 GHz and 6.78 MHz, the average power loss density (PLDavg) within the cellular and subcellular organelles is about six and three orders of magnitude higher than that at 1 kHz. Also, in comparison to the background PLDavg within cytoplasm (CP), the intracellular traffic through the nuclear pores (Np) is submitted to three orders of magnitude higher exposure level at 6.78 MHz and 2.5 times higher exposure level at 60 GHz.
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