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引用次数: 3
摘要
本文介绍了一种为介质调制场效应晶体管(DMFET)阵列设计的电流读出平台，用于检测前列腺癌标志物而无需标记。制备了一种由16个DMFET阵列组成的生物传感器芯片。该读出电路采用标准的0.35 μ m CMOS技术，其中包括一个电流积分器和一个10位单斜率模数转换器(ADC)。通过监测DMFET电流的变化，利用所制备的读出电路成功地检测出前列腺癌标志物。
Integrated current readout circuit and DMFET array for label-free detection of cancer marker
This paper describes a current readout platform designed for dielectric modulated field effect transistor (DMFET) arrays to detect a prostate cancer marker without labeling. A chip of 16 DMFET array has been fabricated as a biosensor cartridge. Standard 0.35 mum CMOS technology has been used to fabricate the readout circuit which includes a current integrator and a 10-bit single-slope analog-to-digital converter (ADC). The prostate cancer marker has been successfully detected by monitoring a change of DMFET current with aid of the fabricated readout circuitry.
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