Ihsan Ikhtiarudin, Nesa Agistia, Tria Harlianti, A. Zamri
{"title":"3 '羟基-羟基-羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基3 ' -羟基","authors":"Ihsan Ikhtiarudin, Nesa Agistia, Tria Harlianti, A. Zamri","doi":"10.37859/jp.v10i1.1541","DOIUrl":null,"url":null,"abstract":"Chalcone analogues have attracted the attention of researchers due to their various biological activities. In this study, a chalcone analogue, (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has been synthesized under microwave irradiation and its sunscreen activity has been evaluated by in vitro assay using 96-well microplate reader. Based on the in vitro assay, at concentration of 100-500 µg/ml, the compound showed potential sunscreen activity with %Te value of 5.49 – 0.04 % (extra protection – sunblock), %Tp value of 0.51-0.05 % (sunblock) and SPF value of 18.20 – 32.91 (ultra protection). The assay result showed that the (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has a potency to be developed as active ingredient in sunscreen product.","PeriodicalId":219962,"journal":{"name":"Photon: Jurnal Sain dan Kesehatan","volume":"69 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Sintesis dan Potensi Aktivitas Tabir Surya Senyawa Analog Kalkon Turunan 3’-Hidroksiasetofenon dan 4-Metoksibenzaldehid\",\"authors\":\"Ihsan Ikhtiarudin, Nesa Agistia, Tria Harlianti, A. Zamri\",\"doi\":\"10.37859/jp.v10i1.1541\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chalcone analogues have attracted the attention of researchers due to their various biological activities. In this study, a chalcone analogue, (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has been synthesized under microwave irradiation and its sunscreen activity has been evaluated by in vitro assay using 96-well microplate reader. Based on the in vitro assay, at concentration of 100-500 µg/ml, the compound showed potential sunscreen activity with %Te value of 5.49 – 0.04 % (extra protection – sunblock), %Tp value of 0.51-0.05 % (sunblock) and SPF value of 18.20 – 32.91 (ultra protection). The assay result showed that the (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has a potency to be developed as active ingredient in sunscreen product.\",\"PeriodicalId\":219962,\"journal\":{\"name\":\"Photon: Jurnal Sain dan Kesehatan\",\"volume\":\"69 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photon: Jurnal Sain dan Kesehatan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37859/jp.v10i1.1541\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photon: Jurnal Sain dan Kesehatan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37859/jp.v10i1.1541","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sintesis dan Potensi Aktivitas Tabir Surya Senyawa Analog Kalkon Turunan 3’-Hidroksiasetofenon dan 4-Metoksibenzaldehid
Chalcone analogues have attracted the attention of researchers due to their various biological activities. In this study, a chalcone analogue, (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has been synthesized under microwave irradiation and its sunscreen activity has been evaluated by in vitro assay using 96-well microplate reader. Based on the in vitro assay, at concentration of 100-500 µg/ml, the compound showed potential sunscreen activity with %Te value of 5.49 – 0.04 % (extra protection – sunblock), %Tp value of 0.51-0.05 % (sunblock) and SPF value of 18.20 – 32.91 (ultra protection). The assay result showed that the (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has a potency to be developed as active ingredient in sunscreen product.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
