低碳水化合物饮食会导致心脏病或癌症吗?

Richard M Fleming
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摘要

众所周知,冠状动脉疾病和癌症是炎症变化的结果,炎症变化发生在身体组织内,特别是冠状动脉壁(CAD)和特定器官(如乳腺、结肠)组织内[1-3],而不是血液中。尽管血液和组织之间存在这种明显的差异,但观察饮食和药物影响的医学研究主要利用定性或半定量成像的变化[4-6]、体重和血液检查来监测心脏病和癌症的推定变化。然而,心脏病和癌症的变化不能仅仅通过血液检查来衡量,因为这些血液检查仅仅告诉我们血液中发生了什么,而不是身体组织中发生了什么[7,8]——因此,关于不同饮食或药物的后果以及冠心病和癌症的潜在风险的持续争论[9-14]——以及公众和媒体持续的怀疑和困惑[15-18]。坦率地说,如果不是我花了三十多年的时间来研究我们知识中的一些细节和局限性,并根据我在非专业媒体上读到的东西发表研究报告,我也会同样感到困惑[19-25]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Do Low Carb Diets Cause Heart Disease or Cancer?
It is well recognized that coronary artery disease and cancer are the result of inflammatory changes, which occur within the tissues of the body specifically the walls of the coronary arteries (CAD) and within the specific organ (e.g. breast, colon) tissue in question [1-3] – and not the blood. Despite this obvious difference between blood and tissue, medical studies looking at the impact of diets and drugs have primarily utilized changes in qualitative or at best semi-quantitative imaging [4-6], weight and blood tests to monitor presumed changes in heart disease and cancer. However, changes in heart disease and cancer cannot be measured through the mere use of blood tests alone, since these blood tests merely tell us what is happening within the blood and not what is happening in the tissues of the body proper [7,8] – hence, the persistent debate about the consequences of different diets or drugs, and the potential risk for CAD and cancer [9-14] – and the persistent doubt and confusion by the public and media [15-18]. Frankly, if I hadn’t spent more than three decades working out some of the details and limitations in our knowledge and published studies based upon what I read in the lay press I would be just as confused [19-25].
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