{"title":"一些核受体作为促肝药物的应用点","authors":"V. Ponamarev","doi":"10.52419/3006-2023-8-51-56","DOIUrl":null,"url":null,"abstract":"At present, one of the most promising directions in the search for chemical compounds-candidates for drugs is the fundamental study of signaling molecules, whose main function is to transmit information to the cell through ion channels and nuclear receptors associated with G-protein or with enzymatic activity. One of the fundamental tasks of modern pharmacology - the expansion of the range of hepatotropic drugs with a fundamentally new mechanism of action - is currently being actively solved, including through specific chemical compounds that act on cell nuclear receptors, one of which is obeticholic acid.","PeriodicalId":338753,"journal":{"name":"SPbVetScience : collection of scientific papers","volume":"70 3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Some nuclear receptors as application points for drugs with hepatotropic activity\",\"authors\":\"V. Ponamarev\",\"doi\":\"10.52419/3006-2023-8-51-56\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"At present, one of the most promising directions in the search for chemical compounds-candidates for drugs is the fundamental study of signaling molecules, whose main function is to transmit information to the cell through ion channels and nuclear receptors associated with G-protein or with enzymatic activity. One of the fundamental tasks of modern pharmacology - the expansion of the range of hepatotropic drugs with a fundamentally new mechanism of action - is currently being actively solved, including through specific chemical compounds that act on cell nuclear receptors, one of which is obeticholic acid.\",\"PeriodicalId\":338753,\"journal\":{\"name\":\"SPbVetScience : collection of scientific papers\",\"volume\":\"70 3 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SPbVetScience : collection of scientific papers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52419/3006-2023-8-51-56\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SPbVetScience : collection of scientific papers","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52419/3006-2023-8-51-56","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Some nuclear receptors as application points for drugs with hepatotropic activity
At present, one of the most promising directions in the search for chemical compounds-candidates for drugs is the fundamental study of signaling molecules, whose main function is to transmit information to the cell through ion channels and nuclear receptors associated with G-protein or with enzymatic activity. One of the fundamental tasks of modern pharmacology - the expansion of the range of hepatotropic drugs with a fundamentally new mechanism of action - is currently being actively solved, including through specific chemical compounds that act on cell nuclear receptors, one of which is obeticholic acid.