Effect of multidisciplinary interventions on the quality of life of individuals with multiple sclerosis: a systematic review

Introduction: The study aims to review published literature on multidisciplinary interventions and their effect on quality of life of individuals with multiple sclerosis to produce state-of-the-art recommendations and consistent discipline combinations for optimal holistic patient car Methods: The study thoroughly analyzed papers published between January 2010 and February 2022. The publications are gathered from five critical databases: Cochrane, JSTOR, PEDro, PubMed, and ScienceDirect. With Rayyan, the data is analyzed. Independent reviewers evaluate the quality of the papers included in the review using the PEDro Scale and the Cochrane Collaboration tool. Results: The review includes ten studies with an average of 129 participants for each of the 513 identified articles. In QOL domains, multidisciplinary rehabilitation programs address limits in physical role (p = 0.016), emotional role (p = 0.010), mental wellbeing composite (p = 0.017), and cardiorespiratory fitness (p = 0.017). In addition, it improves Fatigue, as measured by the Chalder Fatigue Scale, the SF-36 vitality subscale, and Fatigue self-efficacy. Only one study found no statistically significant differences in its primary outcome. With 19 individuals, the Level of Activity improved, notably the Timed 50 Meter Walk (p = 0.014), walking speed (p = 0.034), 2- (p = 0.204), and 6-Minute Walk (p = 0.027). Discussion: In terms of quality of life and decrease in fatigue, multidisciplinary interventions have a remarkable impact on the activity level of MS patients. Findings suggest that Multidisciplinary interventions and other treatment combinations are best recommended in patients with MS to improve multicomponents of QoL and different outcomes such as fatigue.