对近年来肠道(微生物群)-脑轴、营养和认知功能之间关系的研究进行综述

T. Pasiak, T. Wiguna, R. Sekartini, Juwalita Surapsari, T. Sundjaya, E. Wasito, R. W. Basrowi, Melissa Stephanie Kartjito
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引用次数: 0

摘要

肠道(微生物群)-脑轴的概念影响着胃肠道、免疫、神经内分泌和代谢系统的发育和功能,这一概念越来越受欢迎。最近的动物研究表明,肠道(微生物群)-脑轴在建立认知功能方面也起着重要作用。众所周知,环境微生物群平衡的破坏会增加儿童的疾病易感性。历史上,人们一直假设神经发育障碍是儿童健康受到破坏的结果。然而,越来越清楚的是,肠道微生物群和中枢神经系统是双向交流的,这可以解释微生物群如何影响认知功能。饮食因素也通过肠道(微生物群)-脑轴在中枢神经系统中发挥重要作用,证明营养在优化认知功能中的重要性。本文对最近发表的研究和现有知识进行综述,旨在阐明肠道(微生物群)-脑轴与认知功能之间的关系,以及可能影响它的变量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The narrative review of recent studies in understanding the relationship between gut (microbiota)-brain axis, nutrition and cognitive function
The concept of the gut (microbiota)-brain axis, which influences the development and function of the gastrointestinal, immune, neuroendocrine, and metabolic systems, is gaining popularity. Recent animal studies have demonstrated that the gut (microbiota)-brain axis also plays a role in establishing cognitive function. It is known that a disruption in the environment's microbiota balance can increase disease susceptibility in children. Historically, it has been hypothesized that neurodevelopmental disorders are the results of a disruption in children’s health. However, it is becoming clear that the gut microbiota and the central nervous system communicate in both directions, which could explain how microbiota affects cognitive function. Dietary factors also play important role in the central nervous system via the gut (microbiota)-brain axis, demonstrating the importance of nutrition in optimizing cognitive function. This narrative review of recently published studies and current knowledge aims to elucidate the relationship between the gut (microbiota)-brain axis and cognitive function, as well as the variables that may influence it.
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