α-syn12肽在高pH溶液中的结构特征

2010 2nd IEEE International Conference on Information Management and Engineering Pub Date : 2010-04-16 DOI:10.1109/ICIME.2010.5477473

Lixia Liu

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引用次数: 0

摘要

采用GROMOS 43A1力场进行温度复制交换分子动力学模拟，研究了a-syn12肽在高pH水溶液中的动力学和结构特性。分离得到的a-syn12肽在高pH水中呈a-螺旋结构，这与其他淀粉样蛋白在中性pH下的结果不同。

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Structural character of α-syn12 peptide in solution at high pH

The dynamics and structural character of a-syn12 peptide in aqueous solution at high pH has been investigated through temperature replica exchange molecular dynamics simulations by using GROMOS 43A1 force field. The isolated a-syn12 peptide adopts in water an a-helix structure at high pH. These results are distinct from other amyloid disease protein at neutral pH.

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2010 2nd IEEE International Conference on Information Management and Engineering

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